Estrone/progesterone/testosterone

Estrone/progesterone/testosterone (E1/P4/T), sold under the brand name Tristeron or Tristerone, is an injectable combination medication of estrone (E1), an estrogen, progesterone (P4), a progestogen, and testosterone (T), an androgen/anabolic steroid, which was used in the treatment of functional uterine bleeding in women.[1][2] It contained 6 mg estrone, 50 mg progesterone, and 25 mg testosterone in microcrystalline aqueous suspension and was administered by intramuscular injection.[1][3][4] The medication was manufactured by Wyeth and was marketed by 1951.[1][5] It is no longer available.[6][7]

E1/P4/T
Combination of
EstroneEstrogen
ProgesteroneProgestogen
TestosteroneAndrogen; Anabolic steroid
Clinical data
Trade namesTristeron, Tristerone
Other namesE1/P4/T
Routes of
administration		Intramuscular injection

See also

References
  1. Hormone und Psyche die Endokrinologie des Alternden Menschen: Fünftes Symposion der Deutschen Gesellschaft für Endokrinologie Freiburg (Breisgau), den 7. bis 9. März 1957. Springer-Verlag. 9 March 2013. pp. 55–. ISBN 978-3-642-87014-9.
  2. Greenblatt, Robert B.; Barfield, Wm. E. (1952). "Hormonal Control of Functional Uterine Bleeding**The estrogen-progesterone-testosterone combinations used in our studies were supplied by the following pharmaceutical companies:Wyeth, Inc.: Tristerone (6 mg. estrone, 50 mg. progesterone, 25 mg. testosterone).Schering Corporation: Steratrin (1 mg. estradiol benzoate, 25 mg. progesterone, 25 mg. testoterone propionate).Sharp and Dohme, Inc.: Lukestra (1.66 mg. estradiol benzoate, 25 mg. progesterone, 25 mg. testosterone propionate).Ayerst, McKenna & Harrison Limited: Premarin Injectable, 20 mg. per vial of 5 c.c.". American Journal of Obstetrics and Gynecology. 63 (1): 153–157. doi:10.1016/S0002-9378(16)38992-X. ISSN 0002-9378.
  3. General Practitioner. American Academy of General Practice. April 1962. p. 109. Estrogen Therapy In an attempt to increase the theoretical effectiveness of testosterone and progesterone, some investigators have added estrogen to the parenteral mixture to form a triad of steroids in an aqueous suspension (Tristerone®).
  4. American Journal of Hospital Pharmacy. American Society of Hospital Pharmacists. 1958. p. 114. Tristerone*, Injection (Progesterone, Testosterone, and Estrone) : 25 mg. of microcrystalline progesterone, 25 mg. of microcrystallinefree testosterone, and 6 mg. (60,000 I.U.) of microcrystalline estrone per 1-cc.
  5. American Professional Pharmacist. American Professional Pharmacist, Incorporated. 1951. p. 515. TRISTERONE (Crystalline Progesterone, Testosterone, and Estrone Wyeth)
  6. https://www.micromedexsolutions.com/
  7. https://www.drugs.com/international/tristeron.html



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