Clogestone acetate

Clogestone acetate (USAN) (developmental code name AY-11440), also known as chlormadinol acetate or as 3β,17α-diacetoxy-6-chloropregna-4,6-diene-20-one,[1] is a steroidal progestin which was investigated as a progestin-only contraceptive and postcoital contraceptive but was never marketed.[2][3][4][5] It is the diacetate ester of clogestone, which, similarly was never marketed.[2] Clogestone acetate produces chlormadinone acetate as an active metabolite.[6][7]

Clogestone acetate
Clinical data
Other namesChlormadinol acetate; AY-11440; 3β,17α-Diacetoxy-6-chloropregna-4,6-diene-20-one
Drug classProgestogen; Progestogen ester
Identifiers
CAS Number
PubChem CID
ChemSpider
UNII
KEGG
ChEMBL
CompTox Dashboard (EPA)
Chemical and physical data
FormulaC25H33ClO5
Molar mass448.97952 g/mol g·mol−1
3D model (JSmol)

See also

References
  1. Gerald Litwack (2 December 2012). Biochemical Actions of Hormones. Elsevier. pp. 323–. ISBN 978-0-323-15189-4.
  2. J. Elks (14 November 2014). The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies. Springer. pp. 297–. ISBN 978-1-4757-2085-3.
  3. D F Hawkins; M G Elder (22 October 2013). Human Fertility Control: Theory and Practice. Elsevier Science. pp. 3–. ISBN 978-1-4831-6361-1.
  4. JUCKER (8 March 2013). Progress in Drug Research / Fortschritte der Arzneimittelforschung / Progrès des rechersches pharmaceutiques. Birkhäuser. pp. 321–. ISBN 978-3-0348-7098-6.
  5. Hinselmann M, Jürgensen O, Hasselblatt I, Otten U, Prinz W, Taubert HD (1970). "[Clogestone acetate, a new orally effective progestagen]". Arch Gynakol (in German). 209 (2): 136–48. PMID 5537778.
  6. Stern, Michael D.; Givner, Morris L. (1975). "MEASUREMENT OF SERUM CLOGESTONE ACETATE (AY-11, 440) BY A RADIORECEPTOR ASSAY: PRACTICAL APPROACH TO THE QUANTITATIVE DETERMINATION OF SYNTHETIC PROGESTINS". The Journal of Clinical Endocrinology & Metabolism. 40 (4): 728–731. doi:10.1210/jcem-40-4-728. ISSN 0021-972X.
  7. Nuclear Science Abstracts. Oak Ridge Directed Operations, Technical Information Division. July 1975. p. 127.



This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.