List of estrogens

This is a list of steroidal estrogens or derivatives of estradiol, estrone, and estriol. Most esters of these estrogens are not included in this list; for esters, see here instead.

Estradiol, the prototypical estrogen.
Steroid ring system.

Estradiol derivatives

Compound Chemical name Structure Marketed
Estradiol (E2) Estra-1,3,5(10)-triene-3,17β-diol
2-Hydroxyestradiol 2-Hydroxyestradiol
4-Hydroxyestradiol 4-Hydroxyestradiol
4-Methoxyestradiol 4-Methoxyestradiol
8β-VE2 8β-Vinylestradiol
16α-IE2 16α-Iodoestradiol
16α-LE2 Estradiol 21,16α-lactone?
Cloxestradiol Estradiol 17β-chloral hemiacetal ether
Cloxestradiol acetate Estradiol 17β-chloral hemiacetal ether O,O-diacetate
Estradiol sulfate Estradiol 3-sulfate
Estrapronicate Estradiol 3-propionate 17β-nicotinate
Orestrate Estradiol 3-propionate 17β-(1-cyclohexenyl) ether
Polyestradiol phosphate Estradiol 17β-phosphate polymer
Promestriene Estradiol 3-propyl 17β-methyl diether

17α-Substituted estradiol derivatives

Compound Chemical name Structure Marketed
Cyclodiol 14α,17α-Ethanoestradiol
Estrazinol 8-Aza-17α-ethynylestradiol 3-methyl ether
Estrofurate 17α-(3-Furyl)-δ7-estradiol 3-acetate
Etamestrol (eptamestrol) 1-Hydroxy-7α-methyl-17α-ethynylestradiol 1,3-dibenzoate
Ethinylestradiol (EE) 17α-Ethynylestradiol
Ethinylestradiol sulfonate (EES) 17α-Ethynylestradiol 3-isopropylsulfonate
Ethylestradiol 17α-Ethylestradiol
Mestranol (EE3ME) 17α-Ethynylestradiol 3-methyl ether
Methylestradiol 17α-Methylestradiol
Moxestrol 11β-Methoxy-17α-ethynylestradiol
Quinestrol 17α-Ethynylestradiol 3-cyclopentyl ether
RU-16117 11α-Methoxy-17α-ethynylestradiol

Nitrogen mustard-coupled alkylating antineoplastic estradiol derivatives

Compound Chemical name Structure Marketed
Alestramustine Estradiol 3-(bis(2-chloroethyl)carbamate) 17β-(2β-aminopropanoate)
Atrimustine Estradiol 3-benzoate 17β-(4-(4-(bis(2-chloroethyl)amino)phenyl)-1-oxobutoxy)acetate
Estramustine Estradiol 3-(bis(2-chloroethyl)carbamate)
Estramustine phosphate Estradiol 3-(bis(2-chloroethyl)carbamate) 17β-phosphate

17β-Aminoestrogens

Compound Chemical name Structure Marketed
Aminoestradiol 17β-Aminoestradiol
Butolame 17β-((4-Hydroxybutyl)amino)estradiol
Hexolame 17β-((6-Hydroxyhexyl)amino)estradiol
Pentolame 17β-((5-Hydroxypentyl)amino)estradiol
Prodiame 17β-((3-Aminopropyl)amino)estradiol
Prolame 17β-((3-Hydroxypropyl)amino)estradiol

Estrone derivatives

Compound Chemical name Structure Marketed
Estrone (E1) Estra-1,3,5(10)-triene-3-ol-17-one
2-Hydroxyestrone 2-Hydroxyestrone
4-Hydroxyestrone 4-Hydroxyestrone
4-Methoxyestrone 4-Methoxyestrone
16α-Hydroxyestrone 16α-Hydroxyestrone
Almestrone 7α-Methylestrone
Clomestrone 16α-Chloroestrone 3-methyl ether
Estrone sulfate Estrone 3-sulfate
Estropipate Estrone 3-sulfate piperazine salt
Hydroxyestrone diacetate 16α-Hydroxyestrone 3,16α-diacetate

Nitrogen mustard-coupled alkylating antineoplastic estrone derivatives

Compound Chemical name Structure Marketed
Estromustine Estrone 3-(bis(2-chloroethyl)carbamate)

Estriol derivatives

Compound Chemical name Structure Marketed
Estriol (E3) 16α-Hydroxyestradiol
Estetrol (E4) 15α-Hydroxyestriol
Quinestradol Estriol 3-cyclopentyl ether

17α-Substituted estriol derivatives

Compound Chemical name Structure Marketed
Cyclotriol 14α,17α-Ethanoestriol
Ethinylestriol 17α-Ethynylestriol
Nilestriol 17α-Ethynylestriol 3-cyclopentyl ether

Other estrogen derivatives

Epimers

Compound Chemical name Structure Marketed
17α-Estradiol (alfatradiol) 17α-Estradiol
16β-Epiestriol (epiestriol) 16β-Hydroxy-17β-estradiol
17α-Epiestriol 16α-Hydroxy-17α-estradiol
16β,17α-Epiestriol 16β-Hydroxy-17α-estradiol
Epimestrol 17α-Epiestriol 3-methyl ether
Mytatrienediol 16α-Methyl-16β-epiestriol 3-methyl ether

Equine estrogens

Compound Chemical name Structure Marketed
Equilin Δ7-Estrone
Equilenin Δ6,8-Estrone
17α-Dihydroequilin Δ7-17α-Estradiol
17β-Dihydroequilin Δ7-17β-Estradiol
17α-Dihydroequilenin Δ6,8-17α-Estradiol
17β-Dihydroequilenin Δ6,8-17β-Estradiol
8,9-Dehydroestrone Δ8-Estrone
8,9-Dehydroestradiol Δ8-17β-Estradiol
Hippulin Δ8-14-Isoestrone

See also

Notes

? = Chemical names that are unverified.

References


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