Dienestrol diacetate

Dienestrol diacetate
Clinical data
Trade names	Faragynol, Gynocyrol
Drug class	Nonsteroidal estrogen; Estrogen ester
Identifiers
	IUPAC name [4-[(2Z,4E)-4-(4-acetyloxyphenyl)hexa-2,4-dien-3-yl]phenyl] acetate;
CAS Number	84-19-5;
PubChem CID	24884313;
ChemSpider	4707742;
UNII	D20D148WPQ;
ChEMBL	ChEMBL3188355;
Chemical and physical data
Formula	C22H22O4
Molar mass	350.414 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES C\C=C(c1ccc(OC(C)=O)cc1)/C(=C/C)c2ccc(OC(C)=O)cc2;
	InChI InChI=1S/C22H22O4/c1-5-21(17-7-11-19(12-8-17)25-15(3)23)22(6-2)18-9-13-20(14-10-18)26-16(4)24/h5-14H,1-4H3/b21-5-,22-6+; Key:YWLLGDVBTLPARJ-LWKKFVLGSA-N;

Dienestrol diacetate (brand names Faragynol, Gynocyrol, others) is a synthetic nonsteroidal estrogen of the stilbestrol group related to diethylstilbestrol.[1] It is an ester of dienestrol.[1]

Oral potencies of estrogens
Estrogen	Type	Class	ETD (mg/14 days)	EPD (mg/14 days)	EPD (mg/day)	MSD (mg/14 days)	MSD (mg/day)	TSD (mg/day)
Estradiol (non-micronized)	Bioidentical	Steroidal	?	≥120–300	?	?	?	?
Estradiol (micronized)	Bioidentical	Steroidal	?	60–80	4.3	14–28	1.0–2.0	>8
Estradiol valerate	Bioidentical	Steroidal	6–10	60–80	4.3	14–28	1.0–2.0	>8
Estradiol benzoate	Bioidentical	Steroidal	?	60–140	4.5	?	?	?
Estriol	Bioidentical	Steroidal	20^a	120–150^b	10.0–10.7^b	28–84	1.0–6.0	?
Estriol succinate	Bioidentical	Steroidal	?	140–150^b	10.0–10.7^b	28–84	2.0–6.0	?
Conjugated estrogens	Natural	Steroidal	5–12	60–80	4.3	8.4–17.5	0.625–1.25	7.5
Ethinylestradiol	Synthetic	Steroidal	0.2	1.0–2.0	0.071–0.11	0.28	0.02–0.04	0.1
Mestranol	Synthetic	Steroidal	0.3	1.5–3.0	0.11–0.13	0.3–0.5	0.025	?
Quinestrol	Synthetic	Steroidal	0.3	2.0–4.0	0.14–0.29	?	0.025–0.05	?
Methylestradiol	Synthetic	Steroidal	?	2.0	?	?	?	?
Diethylstilbestrol	Synthetic	Nonsteroidal	2.5	20–30	1.4–2.1	?	0.5–2.0	3
Diethylstilbestrol dipropionate	Synthetic	Nonsteroidal	?	15–30	1.1–1.4	?	?	?
Dienestrol	Synthetic	Nonsteroidal	?	30	?	?	0.5–4.0	?
Dienestrol diacetate	Synthetic	Nonsteroidal	3–5	30–60	2.9–4.3	?	?	?
Hexestrol	Synthetic	Nonsteroidal	?	70–110	?	?	?	?
Hexestrol diacetate	Synthetic	Nonsteroidal	?	45	?	?	?	?
Chlorotrianisene	Synthetic	Nonsteroidal	?	>100	?	?	?	?
Methallenestril	Synthetic	Nonsteroidal	?	400	?	?	?	?
Note: The OID of EE is 0.1 mg/day. Footnotes: ^a = Very variable, often higher. ^b = In divided doses, 3x/day; irregular and atypical proliferation. Sources: See template.

Parenteral potencies and durations of nonsteroidal estrogens
Estrogen	Form	Major brand name(s)	EPD (14 days)	Duration
Diethylstilbestrol (DES)	Oil solution	?	20 mg	3 mg ≈ 3 days
Diethylstilbestrol dipropionate	Oil solution	Cyren B	12.5–15 mg	2.5 mg ≈ 5 days
Diethylstilbestrol dipropionate	Aqueous suspension	?	5 mg	? mg = 21–28 days
Dimestrol (DES dimethyl ether)	Oil solution	Depot-Cyren, Depot-Oestromon, Retalon Retard	20–40 mg	?
Fosfestrol (DES diphosphate)^a	Aqueous solution	Honvan	?	<1 day
Dienestrol diacetate	Aqueous suspension	Farmacyrol-Kristallsuspension	50 mg	?
Hexestrol dipropionate	Oil solution	Hormoestrol, Retalon Oleosum	25 mg	?
Hexestrol diphosphate^a	Aqueous solution	Cytostesin, Pharmestrin, Retalon Aquosum	?	Very short
Note: All by intramuscular injection unless otherwise noted. Footnotes: ^a = By intravenous injection. Sources: See template.

References

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