Nitromifene

Nitromifene
Clinical data
Other names	CI-728; CN-5518; CN-55945
Identifiers
	IUPAC name 1-[2-[4-[1-(4-Methoxyphenyl)-2-nitro-2-phenylethenyl]phenoxy]ethyl]pyrrolidine;
CAS Number	10448-84-7 ; 5863-35-4 (citrate);
PubChem CID	22150;
ChemSpider	20796;
UNII	5FS1NJ6Q8N;
Chemical and physical data
Formula	C27H28N2O4
Molar mass	444.531 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES COC1=CC=C(C=C1)C(=C(C2=CC=CC=C2)[N+](=O)[O-])C3=CC=C(C=C3)OCCN4CCCC4;
	InChI InChI=1S/C27H28N2O4/c1-32-24-13-9-21(10-14-24)26(27(29(30)31)23-7-3-2-4-8-23)22-11-15-25(16-12-22)33-20-19-28-17-5-6-18-28/h2-4,7-16H,5-6,17-20H2,1H3; Key:MFKMXUFMHOCZHP-UHFFFAOYSA-N;

Nitromifene (INN; also as the citrate salt nitromifene citrate (USAN), developmental code names CI-728, CN-5518, CN-55945) is a nonsteroidal selective estrogen receptor modulator (SERM) related to triphenylethylenes like tamoxifen that was never marketed.[1] It is a mixture of (E)- and (Z)-isomers that possess similar antiestrogenic activity.[2] The drug was described in 1966.[1] Along with tamoxifen, nafoxidine, and clomifene, it was one of the earliest SERMs.[3]

References

J. Elks (14 November 2014). The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies. Springer. pp. 880–. ISBN 978-1-4757-2085-3.
Raymond Eller Kirk; Donald Frederick Othmer (1980). Encyclopedia of chemical technology. Wiley. p. 676. ISBN 978-0-471-02065-3.
Jordan VC, Morrow M (1999). "Tamoxifen, raloxifene, and the prevention of breast cancer". Endocr. Rev. 20 (3): 253–78. doi:10.1210/edrv.20.3.0368. PMID 10368771.

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