Panomifene

Panomifene
Clinical data
Other names	GYKI-13504; EGIS-5650
Identifiers
	IUPAC name 2-[2-[4-[(E)-3,3,3-trifluoro-1,2-diphenylprop-1-enyl]phenoxy]ethylamino]ethanol;
CAS Number	77599-17-8;
PubChem CID	3033654;
ChemSpider	2298282;
UNII	GCW5E728OC;
ChEMBL	ChEMBL2105273;
Chemical and physical data
Formula	C25H24F3NO2
Molar mass	427.467 g/mol g·mol−1
3D model (JSmol)	Interactive image;
	SMILES C1=CC=C(C=C1)/C(=C(/C2=CC=CC=C2)\C(F)(F)F)/C3=CC=C(C=C3)OCCNCCO;
	InChI InChI=1S/C25H24F3NO2/c26-25(27,28)24(21-9-5-2-6-10-21)23(19-7-3-1-4-8-19)20-11-13-22(14-12-20)31-18-16-29-15-17-30/h1-14,29-30H,15-18H2/b24-23+; Key:MHXVDXXARZCVRK-WCWDXBQESA-N;

Panomifene (INN) (former developmental code names GYKI-13504, EGIS-5650) is a nonsteroidal selective estrogen receptor modulator (SERM) of the triphenylethylene group related to tamoxifen that was under development as an antineoplastic agent by Egis Pharmaceuticals and IVAX Drug Research Institute in the 1990s for the treatment of breast cancer but was not marketed.[1][2][3][4][5][6] It reached phase II clinical trials before development was terminated.[2] The drug was described in 1981.[1]

References

J. Elks (14 November 2014). The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies. Springer. pp. 930–. ISBN 978-1-4757-2085-3.
http://adisinsight.springer.com/drugs/800002425
Michael Oettel; Ekkehard Schillinger (6 December 2012). Estrogens and Antiestrogens I: Physiology and Mechanisms of Action of Estrogens and Antiestrogens. Springer Science & Business Media. pp. 60–. ISBN 978-3-642-58616-3.
Michael Oettel; Ekkehard Schillinger (6 December 2012). Estrogens and Antiestrogens II: Pharmacology and Clinical Application of Estrogens and Antiestrogen. Springer Science & Business Media. pp. 292–. ISBN 978-3-642-60107-1.
Pierre H. Dixneuf; Christian Bruneau (18 October 2014). Ruthenium in Catalysis. Springer. pp. 385–. ISBN 978-3-319-08482-4.
Borvendég J, Hermann I, Csuka O (1996). "Antiestrogens, antiandrogens". Acta Physiol Hung. 84 (4): 405–6. PMID 9328614.

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