Chlorodehydromethyltestosterone

Chlorodehydromethyltestosterone (CDMT; brand name Oral Turinabol) is an anabolic–androgenic steroid (AAS). It is the 4-chloro-substituted derivative of metandienone (dehydromethyltestosterone).

Chlorodehydromethyltestosterone
Clinical data
Other names4-Chlordehydromethyltestosterone; Dehydrochloromethyltestosterone; 4-Chloromethandienone
Pregnancy
category
  • AU: X (High risk)
  • US: X (Contraindicated)
    Routes of
    administration
    By mouth
    Drug classAndrogen; anabolic steroid
    Legal status
    Legal status
    Pharmacokinetic data
    BioavailabilityHigh
    MetabolismLiver
    Elimination half-life16 hours
    ExcretionUrine
    Identifiers
    CAS Number
    PubChem CID
    ChemSpider
    UNII
    CompTox Dashboard (EPA)
    Chemical and physical data
    FormulaC20H27ClO2
    Molar mass334.88 g·mol−1
    3D model (JSmol)
     NY (what is this?)  (verify)

    Side effects

    History

    CDMT was the first original product of Jenapharm, an East German pharmaceutical company. The patent registration took place in 1961. The idea of combining the structures of 4-chlorotestosterone (clostebol) and metandienone originated from the chemist Albert Stachowiak. At the time this represented a unique dissociation of anabolic and androgenic effects after oral administration.[1] The product had been introduced for clinical use from 1965 until 1994 when its production was discontinued.

    Society and culture

    Doping in sports

    CDMT was the key steroid administered to approximately 10,000 athletes from East Germany (GDR) as secret official policy, often without their knowing the nature of the "vitamins" they were forced to take. The doping program was run by the East German Government from about 1968 until 1989 when the GDR collapsed. The doping program was known as State Plan Topic 14.25. The doping was done in secret; it was only in the 1990s that Franke and Berendonk looked closely at the original archived information and discovered the true scope of just how well-planned and successful the doping regime had been (in terms of medal success and world record performances).[2]

    Following allegations by the German documentary of widespread doping the IOC kicked off a reanalysis of Beijing 2008 and London 2012 samples for all sports.

    Weightlifters and sprinters in particular were found to have used CDMT. Most of the doped athletes coming from Russia, Ukraine, and Belarus.[3] However, the method developed by Grigory Rodchenkov in 2011[4] was used in 2016 to detect long-term metabolites of CDMT while retesting the athletes' Olympic samples.

    See also

    References

    1. Schwarz S, Onken D, Schubert A (July 1999). "The steroid story of Jenapharm: from the late 1940s to the early 1970s". Steroids. 64 (7): 439–45. doi:10.1016/S0039-128X(99)00003-3. PMID 10443899.
    2. Franke WW, Berendonk B (July 1997). "Hormonal doping and androgenization of athletes: a secret program of the German Democratic Republic government". Clin. Chem. 43 (7): 1262–79. PMID 9216474.
    3. "Retests of Olympic Doping Samples *15 More Positives from 2008 Announced* - All Things Gym". All Things Gym. 2016-09-09. Retrieved 2016-12-31.
    4. Sobolevsky T, Rodchenkov G (2012). "Detection and mass spectrometric characterization of novel long-term dehydrochloromethyltestosterone metabolites in human urine". The Journal of Steroid Biochemistry and Molecular Biology. 128 (3–5): 121–7. doi:10.1016/j.jsbmb.2011.11.004. PMID 22142641.
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