Phenylbiguanide
Phenylbiguanide (PBG) is a 5-HT3 agonist used to study the role of 5-HT3 receptors in the central nervous system.[1] It has been found to trigger dopamine release in the nucleus accumbens of rats.[2]
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ECHA InfoCard | 100.002.726 |
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Formula | C8H11N5 |
Molar mass | 177.211 g·mol−1 |
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Melting point | 135–142 °C (275–288 °F) |
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Derivatives
- Phenylbiguanide is used to make amanozine and benfosformin.
References
- Higgins, GA; Joharchi, N; Sellers, EM (1993), "Behavioral effects of the 5-hydroxytryptamine3 receptor agonists 1-phenylbiguanide and m-chlorophenylbiguanide in rats.", J Pharmacol Exp Ther, Journal of Pharmacology and Experimental Therapeutics, 264: 1440–9, PMID 8450478
- Chen, JP; van Praag, HM; Gardner, EL (1991), "Activation of 5-HT3 receptor by 1-phenylbiguanide increases dopamine release in the rat nucleus accumbens.", Brain Res, Brain Research., 543 (2): 354–7, doi:10.1016/0006-8993(91)90050-6, PMID 1711914
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