Promazine

Promazine (brand name Sparine) is a medication that belongs to the phenothiazine class of antipsychotics. An older medication used to treat schizophrenia, it is still prescribed, alongside newer agents such as olanzapine and quetiapine. It has predominantly anticholinergic side effects, though extrapyramidal side effects are not uncommon either.

Promazine

Clinical data
AHFS/Drugs.com	Micromedex Detailed Consumer Information
MedlinePlus	a600010
ATC code	N05AA03 (WHO)
Pharmacokinetic data
Protein binding	94%
Elimination half-life	20-40 hr
Identifiers
IUPAC name N,N-dimethyl-3-(10H-phenothiazin-10-yl)-propan-1-amine
CAS Number	58-40-2 Y
PubChem CID	4926
IUPHAR/BPS	7281
DrugBank	DB00420 Y
ChemSpider	4757 Y
UNII	O9M39HTM5W
ChEBI	CHEBI:8459 Y
ChEMBL	ChEMBL564 Y
CompTox Dashboard (EPA)	DTXSID2023517
ECHA InfoCard	100.000.347
Chemical and physical data
Formula	C17H20N2S
Molar mass	284.42 g/mol g·mol−1
3D model (JSmol)	Interactive image
SMILES CN(C)CCCN1c2ccccc2Sc3c1cccc3
InChI InChI=1S/C17H20N2S/c1-18(2)12-7-13-19-14-8-3-5-10-16(14)20-17-11-6-4-9-15(17)19/h3-6,8-11H,7,12-13H2,1-2H3 Y Key:ZGUGWUXLJSTTMA-UHFFFAOYSA-N Y
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Promazine has been approved for human use in the United States, although it has been discontinued.[1] It is available in the US for veterinary use under the names Promazine and Tranquazine.