EGIS-7625

EGIS-7625 is a selective and competitive 5-HT2B receptor antagonist. It is experimentally proven to be directly associated with smooth stomach muscle construction of white rats in vivo, and variably effective in provoking a similar response in in vitro human stomach cells. In high blood concentrations, it causes mild constriction of rabbit pulmonary arteries.[1]

EGIS-7625
Clinical data
ATC code
  • none
Legal status
Legal status
  • UN: Unscheduled
Identifiers
CAS Number
PubChem CID
ChemSpider
Chemical and physical data
FormulaC18H22N4O2
Molar mass326.400 g·mol−1
3D model (JSmol)

References
  1. Kovács, Anikó; Gacsályi, Istvan; Wellmann, János; Schmidt, Éva; Szücs, Zsuzsanna; Dubreuil, Valérie; Nicolas, Jean Paul; Boutin, Jean; et al. (2003). "Effects of EGIS-7625, a Selective and Competitive 5-HT2B Receptor Antagonist". Cardiovascular Drugs and Therapy. 17 (5/6): 427–34. doi:10.1023/B:CARD.0000015857.96371.43. PMID 15107597.
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