LY-310762

LY-310762
Identifiers
	IUPAC name 3,3-Dimethyl-1-(2-[4-(4-fluorobenzoyl)piperidin-1-yl]-1-ethyl)-1,3-dihydro-2H-indol-2-one;
PubChem CID	4282258;
ChemSpider	3488832;
ChEBI	CHEBI:140937;
Chemical and physical data
Formula	C24H27FN2O2
Molar mass	394.481 g/mol g·mol−1
3D model (JSmol)	Interactive image;
	SMILES c3cc(F)ccc3C(=O)C2CCN(CC2)CCN1C(=O)C(C)(C)c4c1cccc4;
	InChI InChI=1S/C24H27FN2O2/c1-24(2)20-5-3-4-6-21(20)27(23(24)29)16-15-26-13-11-18(12-14-26)22(28)17-7-9-19(25)10-8-17/h3-10,18H,11-16H2,1-2H3; Key:KDXISMANFPJVJY-UHFFFAOYSA-N;
(verify)

LY-310762 is a drug which acts as a potent and selective antagonist for the 5-HT_1D serotonin receptor, with reasonable selectivity over the closely related 5-HT_1B subtype.[1]

References

Pullar IA, Boot JR, Broadmore RJ, Eyre TA, Cooper J, Sanger GJ, Wedley S, Mitchell SN (June 2004). "The role of the 5-HT1D receptor as a presynaptic autoreceptor in the guinea pig". European Journal of Pharmacology. 493 (1–3): 85–93. doi:10.1016/j.ejphar.2004.04.029. PMID 15189767.

This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.

[pmid15189767-1] Pullar IA, Boot JR, Broadmore RJ, Eyre TA, Cooper J, Sanger GJ, Wedley S, Mitchell SN (June 2004). "The role of the 5-HT1D receptor as a presynaptic autoreceptor in the guinea pig". European Journal of Pharmacology. 493 (1–3): 85–93. doi:10.1016/j.ejphar.2004.04.029. PMID 15189767.