Roluperidone
Roluperidone (former developmental code names MIN-101, CYR-101, MT-210) is a 5-HT2A and σ2 receptor antagonist that is under development by Minerva Neurosciences for the treatment of schizophrenia.[1][2][3][4] One of its metabolites also has some affinity for the H1 receptor.[2] As of May 2018, the drug is in phase III clinical trials.[5]
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Other names | MIN-101; CYR-101; MT-210 |
Routes of administration | By mouth |
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Formula | C22H23F2N2O2 |
Molar mass | 366.436 g/mol g·mol−1 |
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References
- Mestre, Tiago A; Zurowski, Mateusz; Fox, Susan H (2013). "5-Hydroxytryptamine 2A receptor antagonists as potential treatment for psychiatric disorders". Expert Opinion on Investigational Drugs. 22 (4): 411–421. doi:10.1517/13543784.2013.769957. ISSN 1354-3784.
- Ebdrup, Bjørn H; Rasmussen, Hans; Arnt, Jørn; Glenthøj, Birte (2011). "Serotonin 2A receptor antagonists for treatment of schizophrenia". Expert Opinion on Investigational Drugs. 20 (9): 1211–1223. doi:10.1517/13543784.2011.601738. ISSN 1354-3784.
- Köster, Luisa-Sophie; Carbon, Maren; Correll, Christoph U (2014). "Emerging drugs for schizophrenia: an update". Expert Opinion on Emerging Drugs. 19 (4): 511–531. doi:10.1517/14728214.2014.958148. ISSN 1472-8214.
- "Drug Development in Schizophrenia: Summary and Table". Pharmaceutical Medicine. 28 (5): 265–271. 2014. doi:10.1007/s40290-014-0070-6. ISSN 1178-2595.
- "Roluperidone". AdisInsight.
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See also: Receptor/signaling modulators |
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