Buclizine
Buclizine is an antihistamine and anticholinergic of the diphenylmethylpiperazine group. It is considered to be an antiemetic, similar to meclizine.[1]
 | |
| Clinical data | |
|---|---|
| AHFS/Drugs.com | Micromedex Detailed Consumer Information |
| ATC code | |
| Identifiers | |
IUPAC name
| |
| CAS Number |
|
| PubChem CID | |
| IUPHAR/BPS | |
| DrugBank |
|
| ChemSpider |
|
| UNII | |
| ChEBI | |
| ChEMBL | |
| CompTox Dashboard (EPA) | |
| ECHA InfoCard | 100.001.317  |
| Chemical and physical data | |
| Formula | C28H33ClN2 |
| Molar mass | 433.028 g/mol g·mol−1 |
| 3D model (JSmol) | |
| Chirality | Racemic mixture |
SMILES
| |
InChI
| |
  | |
In the United Kingdom, buclizine is one of three drugs contained in Migraleve tablets, marketed by McNeil Healthcare at migraine sufferers.[2]
References
- Mostafa GA, Al-Badr AA (2011). "Buclizine". Profiles Drug Subst Excip Relat Methodol. Profiles of Drug Substances, Excipients and Related Methodology. 36: 1–33. doi:10.1016/B978-0-12-387667-6.00001-4. ISBN 9780123876676. PMID 22469258.
- Behrendt WA, Cserepes J (1985). "Acute toxicity and analgesic action of a combination of buclizine, codeine and paracetamol ('Migraleve') in tablet and suppository form in rats". Pharmatherapeutica. 4 (5): 322–31. PMID 4070325.
| Benzimidazoles (*) | |
|---|---|
| Diarylmethanes |
|
| Ethylenediamines | |
| Tricyclics | |
| Others |
|
| For topical use | |
| Simple piperazines (no additional rings) |
|
|---|---|
| Phenylpiperazines |
|
| Benzylpiperazines | |
| Diphenylalkylpiperazines (benzhydrylalkylpiperazines) |
|
| Pyrimidinylpiperazines |
|
| Pyridinylpiperazines |
|
| Benzo(iso)thiazolylpiperazines | |
| Tricyclics (piperazine attached via side chain) |
|
| Others/Uncategorized |
|
This article is issued from
Wikipedia.
The text is licensed under Creative
Commons - Attribution - Sharealike.
Additional terms may apply for the media files.