L-745,870

L-745,870
Identifiers
	IUPAC name 3-([4-(4-chlorophenyl)piperazin-1-yl]methyl)-1H-pyrrolo[2,3-b]pyridine;
CAS Number	158985-00-3 ;
PubChem CID	5311200;
IUPHAR/BPS	3303;
ChemSpider	4470720 ;
ChEMBL	ChEMBL267014 ;
CompTox Dashboard (EPA)	DTXSID40415513 ;
Chemical and physical data
Formula	C18H19ClN4
Molar mass	326.822 g/mol g·mol−1
3D model (JSmol)	Interactive image;
	SMILES c1cc2c(c[nH]c2nc1)CN3CCN(CC3)c4ccc(cc4)Cl;
	InChI InChI=1S/C18H19ClN4/c19-15-3-5-16(6-4-15)23-10-8-22(9-11-23)13-14-12-21-18-17(14)2-1-7-20-18/h1-7,12H,8-11,13H2,(H,20,21) ; Key:OGJGQVFWEPNYSB-UHFFFAOYSA-N ;
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L-745,870 is a drug which acts as a dopamine receptor antagonist selective for the D₄ subtype, and has antipsychotic effects in animal models, though it was not effective in human trials.[1][2][3]

References

Bristow LJ, Kramer MS, Kulagowski J, Patel S, Ragan CI, Seabrook GR (June 1997). "Schizophrenia and L-745,870, a novel dopamine D4 receptor antagonist". Trends in Pharmacological Sciences. 18 (6): 186–8. doi:10.1016/s0165-6147(97)01066-3. PMID 9226994.
Zhang K, Grady CJ, Tsapakis EM, Andersen SL, Tarazi FI, Baldessarini RJ (September 2004). "Regulation of working memory by dopamine D4 receptor in rats". Neuropsychopharmacology. 29 (9): 1648–55. doi:10.1038/sj.npp.1300491. PMID 15138447.
Moustgaard A, Hau J, Lind NM (2008). "Effects of dopamine D4 receptor antagonist on spontaneous alternation in rats". Behavioral and Brain Functions. 4: 49. doi:10.1186/1744-9081-4-49. PMC 2577092. PMID 18945334.

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[pmid9226994-1] Bristow LJ, Kramer MS, Kulagowski J, Patel S, Ragan CI, Seabrook GR (June 1997). "Schizophrenia and L-745,870, a novel dopamine D4 receptor antagonist". Trends in Pharmacological Sciences. 18 (6): 186–8. doi:10.1016/s0165-6147(97)01066-3. PMID 9226994.

[pmid15138447-2] Zhang K, Grady CJ, Tsapakis EM, Andersen SL, Tarazi FI, Baldessarini RJ (September 2004). "Regulation of working memory by dopamine D4 receptor in rats". Neuropsychopharmacology. 29 (9): 1648–55. doi:10.1038/sj.npp.1300491. PMID 15138447.

[pmid18945334-3] Moustgaard A, Hau J, Lind NM (2008). "Effects of dopamine D4 receptor antagonist on spontaneous alternation in rats". Behavioral and Brain Functions. 4: 49. doi:10.1186/1744-9081-4-49. PMC 2577092. PMID 18945334.