Fluspirilene
Fluspirilene (Redeptin, Imap, R6218) is a diphenylbutylpiperidine typical antipsychotic drug, used for the treatment of schizophrenia.[1] It is administered intramuscularly.[2] It was discovered at Janssen Pharmaceutica in 1963.[3] A 2007 systematic review investigated the efficacy of fluspirilene decanoate for people with schizophrenia:
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Participant numbers in each comparison were small so power to identify clear difference is limited. Randomized controlled trial data identified no clear differences between the long-acting injection of fluspirilene and oral medication for outcomes that include adverse effects.[4] | ||||||||||||||||||||||||||||||||||||||||
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Routes of administration | IM |
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ECHA InfoCard | 100.015.835 |
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Formula | C29H31F2N3O |
Molar mass | 475.573 g/mol g·mol−1 |
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References
- van Epen JH (1970). "Experience with fluspirilene (R 6218), a long-acting neuroleptic". Psychiatr Neurol Neurochir. 73 (4): 277–284. PMID 5478771.
- Janssen PA, Niemegeers CJ, Schellekens KH, Lenaerts FM, Verbruggen FJ, van Nueten JM, Marsboom RH, Hérin VV, Schaper WK (1970). "The pharmacology of fluspirilene (R 6218), a potent, long-acting and injectable neuroleptic drug". Arzneimittelforschung. 20 (11): 1689–1698. PMID 4992598.
- C. Janssen, NV Res. Lab., BE 633914 (1963)
- Abhijnhan, A; Adams, C; David, A (2007). "Depot fluspirilene for schizophrenia". Cochrane Database of Systematic Reviews. 1: CD001718.pub2. doi:10.1002/14651858.CD001718.pub2.
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See also: Receptor/signaling modulators • Monoamine metabolism modulators • Monoamine reuptake inhibitors |
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