Periciazine

Periciazine (INN), also known as pericyazine (BAN) or propericiazine, is a drug that belongs to the phenothiazine class of typical antipsychotics.

Periciazine
Clinical data
Pregnancy
category
  • AU: C
    Routes of
    administration    		Oral
    ATC code
    Legal status
    Legal status
    • AU: S4 (Prescription only)
    • CA: ℞-only
    • UK: POM (Prescription only)
    • In general: ℞ (Prescription only)
    Pharmacokinetic data
    MetabolismHepatic (mostly via conjugation)[1]
    Elimination half-life12 h[1]
    ExcretionRenal[1]
    Identifiers
    CAS Number
    PubChem CID
    DrugBank
    ChemSpider
    UNII
    KEGG
    ChEBI
    ChEMBL
    CompTox Dashboard (EPA)
    ECHA InfoCard100.018.248
    Chemical and physical data
    FormulaC21H23N3OS
    Molar mass365.49 g/mol g·mol−1
    3D model (JSmol)
     NY (what is this?)  (verify)

    Pericyazine is not approved for sale in the United States. It is commonly sold in Canada and Russia under the tradename Neuleptil and in United Kingdom and Australia under the tradename Neulactil.[2]

    Medical uses

    The primary uses of pericyazine include in the short-term treatment of severe anxiety or tension and in the maintenance treatment of psychotic disorders such as schizophrenia. There is insufficient evidence to determine whether periciazine is more or less effective than other antipsychotics.[1] A 2014 systematic review compared pericyazine with typical antipsychotics for schizophrenia:

    Pericyazine versus typical antipsychotic for schizophrenia[3]
    Summary
    On the basis of very low quality evidence it is not possible to determine the effects of pericyazine in comparison with antipsychotics such as chlorpromazine or trifluoperazine for the treatment of schizophrenia. There is some evidence, however, that pericyazine may be associated with a higher incidence of extrapyramidal side effects than other antipsychotics.[3]

    Periciazine has also been studied in the treatment of opioid dependence.[4]

    Adverse effects

    Pericyazine is a rather sedating and anticholinergic antipsychotic, and despite being classed with the typical antipsychotics, its risk of extrapyramidal side effects is comparatively low.[5] It has a relatively high risk of causing hyperprolactinaemia and a moderate risk of causing weight gain and orthostatic hypotension.[5]

    References
    1. "NEULACTIL PRODUCT INFORMATION" (PDF). TGA eBusiness Services. sanofi-aventis australia pty ltd. 13 September 2011. Retrieved 2 November 2013.
    2. Pericyazine. Martindale: The Complete Drug Reference. The Royal Pharmaceutical Society of Great Britain. 23 September 2011. Retrieved 2 November 2013.
    3. Matar, H; Almerie, M; Makhoul, S (2014). "Pericyazine for schizophrenia". Cochrane Database of Systematic Reviews. 5: CD007479.pub2. doi:10.1002/14651858.CD007479.pub2.
    4. Sivolap IuP, Savchenkov VA (1999). "[The use of neuroleptics in treating opiate dependence]". Zh Nevrol Psikhiatr Im S S Korsakova (in Russian). 99 (6): 29–34. PMID 10441864.
    5. "Approximate relative frequency (not intensity) of common adverse effects of antipsychotics (Table 8.21) [NB1]". eTherapeutic Guidelines complete. Therapeutic Guidelines Limited. February 2013. Retrieved 2 November 2013.
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