Desmethoxyfallypride

Desmethoxyfallypride (¹⁸F)
Clinical data
Other names	DMFP (18F)
Pregnancy; category	N/A;
ATC code	none;
Legal status
Legal status	Research compound;
Identifiers
	IUPAC name 5-(3-18F-fluoropropyl)-2-methoxy-N-[(2S)-1-prop-2-enylpyrrolidin-2-yl]methyl]benzamide;
PubChem CID	9543408;
ChemSpider	8580101;
Chemical and physical data
Formula	C19H27FN2O2
Molar mass	333.430818 g/mol g·mol−1
3D model (JSmol)	Interactive image;
	SMILES COC1=C(C=C(C=C1)CCCF)C(=O)NC[C@@H]2CCCN2CC=C;
	InChI InChI=1S/C19H27FN2O2/c1-3-11-22-12-5-7-16(22)14-21-19(23)17-13-15(6-4-10-20)8-9-18(17)24-2/h3,8-9,13,16H,1,4-7,10-12,14H2,2H3,(H,21,23)/t16-/m0/s1; Key:VPBJNBUDASILSQ-INIZCTEOSA-N;

Desmethoxyfallypride is a moderate affinity dopamine D2 receptor/D3 receptor antagonist used in medical research, usually in the form of the radiopharmaceuticals desmethoxyfallypride or DMFP(¹⁸F)[1][2] and has been used in human studies[3][4] as a positron emission tomography (PET) radiotracer.

References

Mukherjee, J; Yang, Z. Y.; Brown, T; Roemer, J; Cooper, M (1996). "18F-desmethoxyfallypride: A fluorine-18 labeled radiotracer with properties similar to carbon-11 raclopride for PET imaging studies of dopamine D2 receptors". Life Sciences. 59 (8): 669–78. doi:10.1016/0024-3205(96)00348-7. PMID 8761017.
Leung, K (2004). "(S)-N-((1-Allyl-2-pyrrolidinyl)methyl)-5-(3-¹⁸Ffluoropropyl)-2-methoxybenzamide". PMID 20641474. Cite journal requires |journal= (help)
Gründer, G; Siessmeier, T; Piel, M; Vernaleken, I; Buchholz, H. G.; Zhou, Y; Hiemke, C; Wong, D. F.; Rösch, F; Bartenstein, P (2003). "Quantification of D2-like dopamine receptors in the human brain with 18F-desmethoxyfallypride". Journal of Nuclear Medicine. 44 (1): 109–16. PMID 12515884.
Siessmeier, T; Zhou, Y; Buchholz, H. G.; Landvogt, C; Vernaleken, I; Piel, M; Schirrmacher, R; Rösch, F; Schreckenberger, M; Wong, D. F.; Cumming, P; Gründer, G; Bartenstein, P (2005). "Parametric mapping of binding in human brain of D2 receptor ligands of different affinities". Journal of Nuclear Medicine. 46 (6): 964–72. PMID 15937307.

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