Estradiol/medroxyprogesterone acetate

Estradiol/medroxyprogesterone acetate (E2/MPA), sold under the brand names Indivina and Tridestra among others, is a combination product of estradiol, an estrogen, and medroxyprogesterone acetate, a progestogen, which is used in menopausal hormone therapy for the treatment of menopausal symptoms.[1] It is taken by mouth.

Health risks in the CEEs/MPA substudy of the Women's Health Initiative
EventRelative Risk CEEs/MPA vs. placebo at 5.2 years (95% CI[note 1])Placebo
(n = 8102)		CEEs/MPA
(n = 8506)
Absolute Risk per 10,000 Women-Years
Coronary heart disease events
( non-fatal myocardial infarction, death)		1.29 (1.02–1.63)
1.32 (1.02–1.72)
1.18 (0.70–1.97)		30
23
6		37
30
7
Invasive breast cancer[lower-alpha 1]1.26 (1.00–1.59)3038
Stroke1.41 (1.07–1.85)2129
Pulmonary embolism2.13 (1.39–3.25)816
Colorectal cancer0.63 (0.43–0.92)1610
Endometrial cancer0.83 (0.47–1.47)65
Hip fracture0.66 (0.45–0.98)1510
Death due to causes other than above0.92 (0.74–1.14)4037
Global Index[lower-alpha 2]1.15 (1.03–1.28)151170
Deep vein thrombosis[lower-alpha 3]2.07 (1.49–2.87)1326
Vertebral fractures[lower-alpha 3]0.66 (0.44–0.98)159
Other osteoporotic fractures[lower-alpha 3]0.77 (0.69–0.86)170131
Sources: See template.
Estradiol /
medroxyprogesterone acetate
Combination of
EstradiolEstrogen
Medroxyprogesterone acetateProgestogen
Clinical data
Trade namesIndivina, Tridestra
Other namesE2/MPA
Routes of
administration		By mouth
Drug classEstrogen; Progestogen
Legal status
Legal status
Identifiers
CAS Number
PubChem CID

See also

Notes and references
  1. Gavin Clunie; Richard W. Keen (2014). Osteoporosis. Oxford University Press. pp. 74–. ISBN 978-0-19-871334-0.
  1. Includes metastatic and non-metastatic breast cancer with the exception of in situ breast cancer.
  2. A subset of the events was combined in a "global index", defined as the earliest occurrence of coronary heart disease events, invasive breast cancer, stroke, pulmonary embolism, endometrial cancer, colorectal cancer, hip fracture, or death due to other causes.
  3. Not included in Global Index.
  1. Nominal confidence intervals unadjusted for multiple looks and multiple comparisons.


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