Buphedrone

Buphedrone, also known as α-methylamino-butyrophenone (MABP), is a stimulant of the phenethylamine and cathinone chemical classes that was first synthesized in 1928.[1] It is legal in most countries as a research chemical, as long as it is not intended for human consumption.

Buphedrone
Clinical data
Trade namesBuphedrone
Routes of
administration		Vaporization, insufflation, Intravenous injection, intramuscular injection, orally, rectal, buccal
ATC code
  • none
Legal status
Legal status
  • DE: Anlage II (Authorized trade only, not prescriptible)
  • UK: Class B
Pharmacokinetic data
ExcretionUrine
Identifiers
CAS Number
PubChem CID
ChemSpider
Chemical and physical data
FormulaC11H15NO
Molar mass177.242 g/mol g·mol−1
3D model (JSmol)
  (verify)

Chemistry

Buphedrone is a beta-ketone and is related to the naturally occurring compounds, cathinone and cathine. It is also related to methamphetamine, differing by the β-ketone substituent (at the beta carbon) and an ethyl group replacing the methyl group at the carbon alpha to the amine. One other name for Buphedrone is : Phenylacetoethyl-methylamine

Buphedrone as free base is very unstable; the ketone is readily reduced to a hydroxyl group, thus forming the corresponding alcohol. Structurally, this occurs when the C=O bond at the Rβ-position is converted into a C-OH bond. Because of this, it is sold as various salts, with a hydrochloride being most common.

Effects

Buphedrone increases spontaneous rodent locomotor activity, potentiates the release of dopamine from dopaminergic nerve terminals in the brain, and causes appetite suppression. It also causes a possibly dangerous effect of decreasing subjective feeling of thirst. The effects of buphedrone have also been compared to methamphetamine, with more euphoria and less physical stimulation. Most commonly reported effects include:

  • Elevated mood, euphoria
  • Increased alertness
  • Dilated pupils (rare)
  • Slurred speech (rare)
  • Increased heart rate
  • Talkativeness
  • Increased empathy and sense of communication
  • Increased sex drive
  • Temporary erectile dysfunction in men
  • Restlessness
  • Insomnia
  • Increased motivation

Depending on the route of administration, the duration varies from approximately 2.5 (IV) to 6 hours (orally) and may be followed by unpleasant symptoms associated with withdrawal, which may include:

  • Dysphoria
  • Tiredness
  • Sweating
  • Loss of concentration

As of October 2015 Buphedrone is a controlled substance in China.[2]

Buphedrone is an Anlage II controlled drug in Germany.

See also

References
  1. Hyde JF, Browning E, Adams R. Synthetic Homologs of d, l-Ephedrine. Journal of the American Chemical Society. 1928; 50(8):2287–2292. doi:10.1021/ja01395a032
  2. "关于印发《非药用类麻醉药品和精神药品列管办法》的通知" (in Chinese). China Food and Drug Administration. 27 September 2015. Retrieved 1 October 2015.
This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.