Isometheptene
Isometheptene (usually as isometheptene mucate) is a sympathomimetic amine sometimes used in the treatment of migraines and tension headaches due to its vasoconstricting properties; that is, it causes constriction (narrowing) of blood vessels (arteries and veins). Along with paracetamol and dichloralphenazone, it is one of the constituents of Amidrine.
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| AHFS/Drugs.com | International Drug Names |
| MedlinePlus | a601064 |
| Routes of administration | Oral |
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| ECHA InfoCard | 100.007.236  |
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| Formula | C9H19N |
| Molar mass | 141.258 g·mol−1 |
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Chemistry
Isometheptene is a monounsaturated aliphatic secondary amine.
Mechanism of action
Isometheptene's vasoconstricting properties arise through activation of the sympathetic nervous system via epinephrine and norepinephrine. These compounds elicit smooth muscle activation leading to vasoconstriction by interacting with cell surface adrenergic receptors.[1]
See also
- Heptaminol
- Methylhexanamine
- Tuaminoheptane
References
- "Isometheptene". Cite journal requires
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Drugs for functional gastrointestinal disorders (A03) | |||||||||||||
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| Drugs for functional bowel disorders |
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| Belladonna and derivatives (antimuscarinics) |
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