Cyclazodone
Cyclazodone is a centrally acting stimulant drug developed by American Cyanamid Company in the 1960s.[1] The drug is related to other drugs such as pemoline and thozalinone. It displayed a favorable therapeutic index and margin of safety in comparison to Pemoline and other N-lower-alkyl-substituted Pemoline derivatives.[2]
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| Routes of administration | Oral |
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| Formula | C12H12N2O2 |
| Molar mass | 216.090 g/mol g·mol−1 |
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| Chirality | Racemic mixture |
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The patents concluded that Cyclazodone possessed properties efficacious in reducing fatigue and as a potential anorectic.[3] Structural congeners of Pemoline have been described as "excitants with unique properties distinguishing them from the sympathomimetic amines" whilst displaying less stimulatory activity and toxicity compared to amphetamine.[4]
It is included under the World Anti-Doping Agency prohibited list.[5]
Safety
Cyclazodone has not been evaluated by the United States Food and Drug Administration for use in humans as a nootropic, anorectic, or stimulant and thus safety information on Cyclazodone is lacking. However, in studies relating to the therapeutic uses of Cyclazodone, it was noted that Cyclazodone exhibited less cardiotoxic and hepatotoxic effects than D-Amphetamine in studies on mice.[6]
See also
References
- US Patent 3,321,470 - 5-Arylidene-2Amino-2-Oxazolin-4-Ones
- Val De Marne, Don Pierre R. L. Guidicelli, and Henry Najer. 5-Phenyl-2-Cyclopropylamino-4-Oxazolinone. Les Laboratoires Dausse, assignee. Patent US3609159. 28 Sept. 1971.
- Val De Marne, Don Pierre R. L. Guidicelli, and Henry Najer. 5-Phenyl-2-Cyclopropylamino-4-Oxazolinone. Les Laboratoires Dausse, assignee. Patent GB1005738A. 29 Sept. 1965
- Greenblatt EN, Osterberg AC. Some pharmacologic properties of thozalinone, a new excitant. Toxicol Appl Pharmacol. 1965;7(4):566-78.
- World Anti-Doping Agency 2008 Prohibited List
- Val De Marne, Don Pierre R. L. Guidicelli, and Henry Najer. 5-Phenyl-2-Cyclopropylamino-4-Oxazolinone. Les Laboratoires Dausse, assignee. Patent US3609159. 28 Sept. 1971.