8-Chlorotheophylline
8-Chlorotheophylline, also known as 1,3-dimethyl-8-chloroxanthine, is a stimulant drug of the xanthine chemical class, with physiological effects similar to caffeine.[1] Its main use is in combination (salt) with diphenhydramine in the antiemetic dimenhydrinate. Diphenhydramine reduces nausea but causes drowsiness, and the stimulant properties of 8-Chlorotheophylline help ward off that side-effect.
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| Routes of administration | Oral |
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| ECHA InfoCard | 100.001.446  |
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| Formula | C7H7ClN4O2 |
| Molar mass | 214.61 g/mol g·mol−1 |
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Despite being classified as a xanthine stimulant, 8-Chlorotheophylline can generally not produce any locomotor activity above control in mice and does not appear to cross the blood-brain barrier well.
References
- S H Snyder; J J Katims; Z Annau; R F Bruns & J W Daly (May 1, 1981). "Adenosine receptors and behavioral actions of methylxanthines". PNAS. 78: 3260–3264. doi:10.1073/pnas.78.5.3260. PMC 319541.
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