8-Chlorotheophylline

8-Chlorotheophylline, also known as 1,3-dimethyl-8-chloroxanthine, is a stimulant drug of the xanthine chemical class, with physiological effects similar to caffeine.[1] Its main use is in combination (salt) with diphenhydramine in the antiemetic dimenhydrinate. Diphenhydramine reduces nausea but causes drowsiness, and the stimulant properties of 8-Chlorotheophylline help ward off that side-effect.

8-Chlorotheophylline
Clinical data
Routes of
administration
Oral
ATC code
  • none
Legal status
Legal status
Identifiers
CAS Number
PubChem CID
ChemSpider
UNII
ChEBI
ChEMBL
CompTox Dashboard (EPA)
ECHA InfoCard100.001.446
Chemical and physical data
FormulaC7H7ClN4O2
Molar mass214.61 g/mol g·mol−1
3D model (JSmol)
 NY (what is this?)  (verify)

Despite being classified as a xanthine stimulant, 8-Chlorotheophylline can generally not produce any locomotor activity above control in mice and does not appear to cross the blood-brain barrier well.

References

  1. S H Snyder; J J Katims; Z Annau; R F Bruns & J W Daly (May 1, 1981). "Adenosine receptors and behavioral actions of methylxanthines". PNAS. 78: 3260–3264. doi:10.1073/pnas.78.5.3260. PMC 319541.


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