Pronethalol
Pronethalol (Alderlin, Nethalide) was an early non-selective beta blocker clinical candidate. It was never used clinically due to carcinogenicity in mice, which was thought to result from formation of a carcinogenic naphthalene epoxide metabolite.[1]
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Routes of administration | Oral |
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Formula | C15H19NO |
Molar mass | 229.32 g/mol g·mol−1 |
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Chirality | Racemic mixture |
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See also
References
- Stapleton MP (1997). "Sir James Black and propranolol. The role of the basic sciences in the history of cardiovascular pharmacology". Tex Heart Inst J. 24 (4): 336–42. PMC 325477. PMID 9456487.
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