Flualprazolam

Flualprazolam is a benzodiazepine derivative which was first synthesised in 1976,[1] but was never marketed. It has subsequently been sold as a designer drug, first being definitively identified in Sweden in 2018.[2] It can be described as the 2'-fluoro derivative of alprazolam, or the fluoro instead of chloro analogue of triazolam, and has similar sedative and anxiolytic effects.[3][4][5][6][7]

Flualprazolam
Legal status
Legal status
Identifiers
CAS Number
PubChem CID
ChemSpider
Chemical and physical data
FormulaC17H12ClFN4
Molar mass326.76 g·mol−1
3D model (JSmol)

Flualprazolam is banned in Sweden.[8] In December 2019, the World Health Organization recommended flualprazolam for international scheduling under the Convention on Psychotropic Substances.[9]

See also

References
  1. Hester JB, et al. 6-Phenyl-4H-s-triazolo[4,3-a][1,4]benzodiazepines. Patent US 3987052
  2. Svenska Narkotika Polisföreningens Tidskrift, June 1 2018
  3. Waters, Laura; Manchester, Kieran R.; Maskell, Peter D.; Haegeman, Caroline; Haider, Shozeb (May 2018). "The use of a quantitative structure-activity relationship (QSAR) model to predict GABA-A receptor binding of newly emerging benzodiazepines". Science & Justice. 58 (3): 219–225. doi:10.1016/j.scijus.2017.12.004. ISSN 1355-0306. PMID 29685303.
  4. Zawilska, Jolanta B.; Wojcieszak, Jakub (July 2019). "An expanding world of new psychoactive substances—designer benzodiazepines". NeuroToxicology. 73: 8–16. doi:10.1016/j.neuro.2019.02.015. ISSN 0161-813X. PMID 30802466.
  5. Moosmann, Bjoern; Auwärter, Volker (October 2018). Designer Benzodiazepines: Another Class of New Psychoactive Substances. Handbook of Experimental Pharmacology. Springer International Publishing. pp. 383–410. doi:10.1007/164_2018_154. ISBN 978-3-030-10561-7. PMID 30367253 – via Springer Link.
  6. Chetraru, Emil; Ameline, Alice; Gheddar, Laurie; Raul, Jean-Sébastien; Kintz, Pascal (February 2018). "Les « designer benzodiazepines » : qu'en sait-on aujourd'hui ?". Toxicologie Analytique et Clinique. 30 (1): 5–18. doi:10.1016/j.toxac.2017.12.001. ISSN 2352-0078.
  7. Mei, Victoria; Concheiro, Marta; Pardi, Justine; Cooper, Gail (August 2019). "Validation of an LC-MS/MS Method for the Quantification of 13 Designer Benzodiazepines in Blood". Journal of Analytical Toxicology. doi:10.1093/jat/bkz063. PMID 31436813.
  8. Riksdagsförvaltningen. "Förordning (1992:1554) om kontroll av narkotika Svensk författningssamling 1992:1992:1554 t.o.m. SFS 2019:611 - Riksdagen". riksdagen.se.
  9. "News: December 2019 – WHO: World Health Organization recommends 12 NPS for scheduling". www.unodc.org.
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