Triazolobenzodiazepine
Triazolobenzodiazepines are a class of benzodiazepine pharmaceutical drugs. Chemically, they differ from other benzodiazepines by having an additional fused triazole ring.
Chemical structure of alprazolam, a common triazolobenzodiazepine
Examples include:
- Adinazolam
- Alprazolam
- Clonazolam
- Estazolam
- Flubromazolam
- Nitrazolam
- Pyrazolam
- Triazolam
- Zapizolam
Synthesis
Synthesis of 1-methyltriazolobenzodiazepines (alprazolam type) is possible by heating 1,4-benzodiazepin-2-thiones with hydrazine and acetic acid in n-butanol under reflux.[1]
References
- Hester JB, Duchamp DJ, Chidester CG (1971): "A synthetic approach to new 1,4-benzodiazepine derivatives." Tetrahedron Letters, Vol. 12, pp. 1609-1612.
This article is issued from
Wikipedia.
The text is licensed under Creative
Commons - Attribution - Sharealike.
Additional terms may apply for the media files.