RU-28306

RU-28306
Identifiers
CAS Number	73625-11-3;
PubChem CID	194528;
ChemSpider	168785;
Chemical and physical data
Formula	C13H16N2
Molar mass	200.279 g/mol g·mol−1
3D model (JSmol)	Interactive image;
	SMILES c13c(C2)cccc1[nH]cc3CC2N(C)C;
	InChI InChI=1S/C13H16N2/c1-15(2)11-6-9-4-3-5-12-13(9)10(7-11)8-14-12/h3-5,8,11,14H,6-7H2,1-2H3; Key:BQOANWOQEHVATQ-UHFFFAOYSA-N;

RU-28306 is a tricyclic tryptamine derivative which acts as a serotonin receptor agonist, with selectivity for 5-HT₁ and 5-HT₂ subtypes. It can be regarded either as a conformationally constrained derivative of DMT, or a structurally simplified analogue of LSD, but the binding affinity of racemic RU-28306 is closer to that of DMT, though with relatively higher affinity for 5-HT₂ subtypes and lower for 5-HT₁.[1] It has been sold as a designer drug and was first reported to the EMCDDA by a forensic laboratory in Slovenia in 2017.[2]

References

Taylor EW, Nikam S, Weck B, Martin A, Nelson D (October 1987). "Relative selectivity of some conformationally constrained tryptamine analogs at 5-HT1, 5-HT1A and 5-HT2 recognition sites". Life Sciences. 41 (16): 1961–9. doi:10.1016/0024-3205(87)90749-1. PMID 3657392.
EMCDDA – Europol 2017 Annual Report on the implementation of Council Decision 2005/387/JHA

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[pmid3657392-1] Taylor EW, Nikam S, Weck B, Martin A, Nelson D (October 1987). "Relative selectivity of some conformationally constrained tryptamine analogs at 5-HT1, 5-HT1A and 5-HT2 recognition sites". Life Sciences. 41 (16): 1961–9. doi:10.1016/0024-3205(87)90749-1. PMID 3657392.

[2] EMCDDA – Europol 2017 Annual Report on the implementation of Council Decision 2005/387/JHA

RU-28306

See also

References