ST-1936

ST-1936
Clinical data
ATC code	none;
Identifiers
	IUPAC name 2-(2-methyl-5-chloro-1H-indol-3-yl)-N,N-dimethylethanamine;
CAS Number	1210-81-7 ;
PubChem CID	9921064;
ChemSpider	8096699;
Chemical and physical data
Formula	C13H17ClN2
Molar mass	236.74 g/mol g·mol−1
3D model (JSmol)	Interactive image;
	SMILES CC1=C(CCN(C)C)C2=CC(Cl)=CC=C2N1;
	InChI InChI=1S/C13H17ClN2/c1-9-11(6-7-16(2)3)12-8-10(14)4-5-13(12)15-9/h4-5,8,15H,6-7H2,1-3H3; Key:KSYMELKKLOFABL-UHFFFAOYSA-N;

ST-1936 (2-methyl-5-chloro-N,N-dimethyltryptamine) is a tryptamine derivative which is used in scientific research. It acts as a selective 5-HT₆ receptor agonist, with a K_i of 13 nM, and much weaker action at 5-HT_2B and 5-HT₇ subtypes. In animal studies it has been found to increase dopamine and noradrenaline mediated signalling but decreases glutamatergic transmission, and has antidepressant effects.[1][2][3][4]

References

Valentini, V.; Frau, R.; Bordi, F.; Borsini, F.; Di Chiara, G. (2011). "A microdialysis study of ST1936, a novel 5-HT6 receptor agonist". Neuropharmacology. 60 (4): 602–608. doi:10.1016/j.neuropharm.2010.12.006. PMID 21185318.
Riccioni, T.; Bordi, F.; Minetti, P.; Spadoni, G.; Yun, H. M.; Im, B. H.; Tarzia, G.; Rhim, H.; Borsini, F. (2011). "ST1936 stimulates cAMP, Ca2+, ERK1/2 and Fyn kinase through a full activation of cloned human 5-HT6 receptors". European Journal of Pharmacology. 661 (1–3): 8–14. doi:10.1016/j.ejphar.2011.04.028. PMID 21549693.
Tassone, A.; Madeo, G.; Schirinzi, T.; Vita, D.; Puglisi, F.; Ponterio, G.; Borsini, F.; Pisani, A.; Bonsi, P. (2011). "Activation of 5-HT6 receptors inhibits corticostriatal glutamatergic transmission". Neuropharmacology. 61 (4): 632–637. doi:10.1016/j.neuropharm.2011.05.004. PMID 21619890.
Scheggi, S.; Marchese, G.; Borsini, F.; Bordi, F.; De Montis, M. G. (2011). "Effects of the 5-HT6 receptor agonist ST 1936 on depression- and anhedonia-like experimental models". Behavioural Brain Research. 224 (1): 35–43. doi:10.1016/j.bbr.2011.05.019. PMID 21645553.

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[1] Valentini, V.; Frau, R.; Bordi, F.; Borsini, F.; Di Chiara, G. (2011). "A microdialysis study of ST1936, a novel 5-HT6 receptor agonist". Neuropharmacology. 60 (4): 602–608. doi:10.1016/j.neuropharm.2010.12.006. PMID 21185318.

[2] Riccioni, T.; Bordi, F.; Minetti, P.; Spadoni, G.; Yun, H. M.; Im, B. H.; Tarzia, G.; Rhim, H.; Borsini, F. (2011). "ST1936 stimulates cAMP, Ca2+, ERK1/2 and Fyn kinase through a full activation of cloned human 5-HT6 receptors". European Journal of Pharmacology. 661 (1–3): 8–14. doi:10.1016/j.ejphar.2011.04.028. PMID 21549693.

[3] Tassone, A.; Madeo, G.; Schirinzi, T.; Vita, D.; Puglisi, F.; Ponterio, G.; Borsini, F.; Pisani, A.; Bonsi, P. (2011). "Activation of 5-HT6 receptors inhibits corticostriatal glutamatergic transmission". Neuropharmacology. 61 (4): 632–637. doi:10.1016/j.neuropharm.2011.05.004. PMID 21619890.

[4] Scheggi, S.; Marchese, G.; Borsini, F.; Bordi, F.; De Montis, M. G. (2011). "Effects of the 5-HT6 receptor agonist ST 1936 on depression- and anhedonia-like experimental models". Behavioural Brain Research. 224 (1): 35–43. doi:10.1016/j.bbr.2011.05.019. PMID 21645553.

ST-1936

See also

References