4′-Fluorococaine

4′-Fluorococaine is a tropane derivative drug which is a synthetic analogue of cocaine. Unlike related compounds such as the corresponding 4′-fluorophenyltropane derivative CFT and the 2′-hydroxy analogue salicylmethylecgonine, 4′-fluorococaine has only around the same potency as cocaine as an inhibitor of dopamine reuptake, but conversely it is a much stronger serotonin reuptake inhibitor than cocaine, resulting in a significantly altered pharmacological profile in animal studies.[1]

4′-Fluorococaine
Legal status
Legal status
Identifiers
CAS Number
PubChem CID
ChemSpider
UNII
Chemical and physical data
FormulaC17H20FNO4
Molar mass321.343 g/mol g·mol−1
3D model (JSmol)
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See also

References
  1. Gatley, S. J.; Yu, D. W.; Fowler, J. S.; MacGregor, R. R.; Schlyer, D. J.; Dewey, S. L.; Wolf, A. P.; Martin, T.; Shea, C. E.; Volkow, N. D. (2008). "Studies with Differentially Labeled [11C]Cocaine, [11C]Norcocaine, [11C]Benzoylecgonine, and [11C]-and 4′-[18F]Fluorococaine to Probe the Extent to Which [11C]Cocaine Metabolites Contribute to PET Images of the Baboon Brain". Journal of Neurochemistry. 62 (3): 1154–1162. doi:10.1046/j.1471-4159.1994.62031154.x. PMID 8113802.


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