Selective androgen receptor degrader
A selective androgen receptor degrader or downregulator (SARD) is a type of drug which interacts with the androgen receptor (AR) such that it causes the AR to be degraded and thus downregulated.[1] They are under investigation for the treatment of prostate cancer and other androgen-dependent conditions.[1]
Not to be confused with Selective androgen receptor modulator.
As of 2017, dimethylcurcumin (ASC-J9), a SARD, is under development for the treatment of acne vulgaris.[2]
See also
References
- Lai, AC; Crews, CM (25 November 2016). "Induced protein degradation: an emerging drug discovery paradigm". Nature Reviews. Drug Discovery. doi:10.1038/nrd.2016.211. PMC 5684876. PMID 27885283.
- http://adisinsight.springer.com/drugs/800028542
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