Dimetindene

Dimetindene is an antihistamine/anticholinergic. It is a first generation[1] selective H1 antagonist.[2] Dimetindene is an atypical first generation H1 antagonist as it only minimally[3] passes across the blood-brain barrier.

Dimetindene
Clinical data
Trade namesFenistil
AHFS/Drugs.comInternational Drug Names
Routes of
administration		Oral, topical
ATC code
Legal status
Legal status
Identifiers
CAS Number
PubChem CID
DrugBank
ChemSpider
UNII
KEGG
ChEMBL
CompTox Dashboard (EPA)
ECHA InfoCard100.024.622
Chemical and physical data
FormulaC20H24N2
Molar mass292.418 g/mol g·mol−1
3D model (JSmol)
ChiralityRacemic mixture
  (verify)

Dimetindene is also an M2 receptor antagonist.[4]

It was patented in 1958 and came into medical use in 1960.[5]

Medical use

Dimetindene is used orally and topically as an antipruritic.[6] It is used topically to treat skin irritations, such as insect bites. Dimetindene is also administered orally to treat allergies, such as hay fever.

It is commonly formulated as its maleic acid salt, dimethindene maleate.

Names

It is sold under the brand name Fenistil among others.

References
  1. Simon, F. Estelle R.; Simons, Keith J. (2008). "H1 Antihistamines: Current Status and Future Directions". World Allergy Organization Journal. 1 (9). doi:10.1186/1939-4551-1-9-145. PMC 3651039.
  2. "Dimetindene". Drugs.com.
  3. "WikiGenes - Collaborative Publishing". WikiGenes - Collaborative Publishing. Archived from the original on 2018-09-13. Retrieved 2019-03-13.
  4. Matsumoto, Yoshihiro; Miyazato, Minoru; Furuta, Akira; Torimoto, Kazumasa; Hirao, Yoshihiko; Chancellor, Michael B.; Yoshimura, Naoki (2010). "Differential Roles of M2 and M3 Muscarinic Receptor Subtypes in Modulation of Bladder Afferent Activity in Rats". Urology. 75 (4): 862–867. doi:10.1016/j.urology.2009.12.013. PMC 2871158. PMID 20156651.
  5. Fischer, Jnos; Ganellin, C. Robin (2006). Analogue-based Drug Discovery. John Wiley & Sons. p. 547. ISBN 9783527607495.
  6. Wexler, L. (1962). "A Clinical Evaluation of Dimethindene". Current Therapeutic Research, Clinical and Experimental. 4: 306–9. PMID 14006402.
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