Talastine
Talastine (trade name Ahanon) is an antihistamine.[1]
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Formula | C19H21N3O |
Molar mass | 307.39 g/mol g·mol−1 |
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Synthesis
The amide proton from 4-Benzylphalazone is abstracted with KOH, which is then alkylated with diethylaminoethyl chloride.[2]
References
- Richter, G.; Kühn, E. (1990). "Talastine (Ahanon) as a cause of allergic drug exanthema". Dermatologische Monatsschrift. 176 (2–3): 111–113. PMID 1973126.
- Engelbrecht et al., DE 1046625; eidem, U.S. Patent 3,017,411 (1958, 1962, both to VEB Deutsches Hydrierwerk Rodleben).
External links
- CTD's Talastine page from the Comparative Toxicogenomics Database
- http://chem2.sis.nlm.nih.gov/chemidplus/direct.jsp?regno=16188-61-7
- https://www.nlm.nih.gov/cgi/mesh/2005/MB_cgi?field=uid&term=C009376
- Toxnet search
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