Dexbrompheniramine

Dexbrompheniramine is an antihistamine with anticholinergic properties[1] used to treat allergic conditions such as hay fever or urticaria. It is the pharmacologically active dextrorotatory isomer of brompheniramine. It was formerly marketed in combination with pseudoephedrine under the name Drixoral in the US and Canada.

Dexbrompheniramine
Clinical data
Trade namesDrixoril, Conex, Dixaphedrine
AHFS/Drugs.comMultum Consumer Information
Pregnancy
category
  • US: C (Risk not ruled out)
    Routes of
    administration    		Oral
    ATC code
    Legal status
    Legal status
    Pharmacokinetic data
    Elimination half-life25 hours
    Identifiers
    CAS Number
    PubChem CID
    IUPHAR/BPS
    DrugBank
    ChemSpider
    UNII
    ChEBI
    ChEMBL
    CompTox Dashboard (EPA)
    ECHA InfoCard100.004.595
    Chemical and physical data
    FormulaC16H19BrN2
    Molar mass319.24 g/mol g·mol−1
    3D model (JSmol)
     NY (what is this?)  (verify)

    Dexbrompheniramine is a first generation antihistamine that reduces the effects of the neurotransmitter histamine in the body; sneezing, itching, watery eyes, and runny nose.

    Interactions

    MAO inhibitors within 14 days. MAO inhibitors include isocarboxazid, linezolid, phenelzine, rasagiline, selegiline, and tranylcypromine.

    Potassium

    Drinking alcohol can increase side effects of dexbrompheniramine.

    References
    1. Löfkvist, T. (1978). "A comparative evaluation of oral decongestants in the treatment of vasomotor rhinitis". The Journal of international medical research. 6 (1): 56–60. doi:10.1177/030006057800600110. PMID 627306.
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