Piperoxan
Piperoxan, also known as benodaine, is a drug which was the very first antihistamine to be discovered.[1][2] This compound, derived from benzodioxan, was prepared in the early 1930s by Daniel Bovet and Ernest Fourneau at the Pasteur Institute in France.[1][2] Formerly investigated by Fourneau as an α-adrenergic-blocking agent, they demonstrated that it also antagonized histamine-induced bronchospasm in guinea pigs, and published their findings in 1933.[1][2][3] Bovet went on to win the 1957 Nobel Prize in Physiology or Medicine for his contribution,[4] and one of their students, Anne-Marie Staub, published the first structure-activity relationship (SAR) study of antihistamines in 1939.[1]
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| Routes of administration | Oral |
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| Formula | C14H19NO2 |
| Molar mass | 233.31 g/mol g·mol−1 |
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See also
References
- Scriabine, Alexander; Landau, Ralph; Achilladelis, Basil (1999). Pharmaceutical innovation: revolutionizing human health. Philadelphia: Chemical Heritage Press. ISBN 0-941901-21-1.
- Williams, David H.; Lemke, Thomas L.; Foye, William O. (2008). Foye's principles of medicinal chemistry. Hagerstwon, MD: Lippincott Williams & Wilkins. ISBN 0-7817-6879-9.
- Fourneau, Ernest; Bovet, Daniel (1933). "Recherches sur l'action sympathicolytique d'un nouveau dérivé du dioxane". Archives Internationales de Pharmacodynamie et de Thérapie. 46: 178–91. ISSN 0003-9780.
- "Daniel Bovet - Biography".
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