Ibogamine

Ibogamine is an alkaloid found in Tabernanthe iboga.[1][2]

Ibogamine
Clinical data
ATC code
  • none
Identifiers
CAS Number
PubChem CID
ChemSpider
ChEBI
Chemical and physical data
FormulaC19H24N2
Molar mass280.41 g/mol g·mol−1
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Basic research related to how addiction affects the brain has used this chemical.[3]

Ibogamine persistently reduced the self-administration of cocaine and morphine in rats.[4]. The same study found that Ibogamine (40mg/kg) and Coronaridine (40mg/kg) did not produce "any tremor effects in rats that differ significantly from saline control". While the related alkaloids Ibogaine(20-40 mg/kg), harmaline (10-40 mg/kg) and desethylcoronaridine (10-40 mg/kg) were "obviously tremorgenic".[4]

See also

References
  1. Bartlett, M. F.; Dickel, D. F.; Taylor, W. I. (1958). "The Alkaloids of Tabernanthe iboga. Part IV.1 The Structures of Ibogamine, Ibogaine, Tabernanthine and Voacangine - Journal of the American Chemical Society (ACS Publications)". Journal of the American Chemical Society. 80 (1): 126–136. doi:10.1021/ja01534a036.
  2. Kuehne, Martin E.; Reider, Paul J. (1985). "A synthesis of ibogamine - The Journal of Organic Chemistry (ACS Publications)". The Journal of Organic Chemistry. 50 (9): 1464–1467. doi:10.1021/jo00209a020.
  3. Levi MS, Borne RF (October 2002). "A review of chemical agents in the pharmacotherapy of addiction". Curr. Med. Chem. 9 (20): 1807–18. doi:10.2174/0929867023368980. PMID 12369879.
  4. Glick SD, Kuehne ME, Raucci J, Wilson TE, Larson D, Keller RW Jr, Carlson JN (September 1994). "Effects of iboga alkaloids on morphine and cocaine self-administration in rats: relationship to tremorigenic effects and to effects on dopamine release in nucleus accumbens and striatum". Brain Res. 657 (1–2): 14–22. doi:10.1016/0006-8993(94)90948-2. PMID 7820611.



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