Ethylmethylthiambutene

Ethylmethylthiambutene (N-ethyl-N-methyl-1-methyl-3,3-di-2-thienylallylamine; Emethibutin) is an opioid analgesic drug from the thiambutene family, around 1.3x the potency of morphine.[1][2][3] It is under international control under Schedule I of the UN Single Convention On Narcotic Drugs 1961, presumably due to high abuse potential. It is a Schedule I controlled substance in the United States with a DEA ACSCN of 9623 and zero annual manufacturing quota as of 2013.

Ethylmethylthiambutene
Clinical data
ATC code
  • none
Legal status
Legal status
  • CA: Schedule I
  • DE: Anlage I (Authorized scientific use only)
  • US: Schedule I
Identifiers
CAS Number
PubChem CID
DrugBank
ChemSpider
UNII
ECHA InfoCard100.006.482
Chemical and physical data
FormulaC15H19NS2
Molar mass277.45 g/mol g·mol−1
3D model (JSmol)
  (verify)

References
  1. Adamson, DW; Green, AF (1950). "A new series of analgesics". Nature. 165 (4186): 122–122. doi:10.1038/165122a0. PMID 15409854.
  2. Adamson, DW; Duffin, WM; Green, AF (1951). "Dithienylbutylamines as analgesics". Nature. 167 (4239): 153–4. doi:10.1038/167153b0. PMID 14806409.
  3. Green, AF (1953). "Analgesic and other properties of 3: 3-dithienylalkenylamines". British Journal of Pharmacology and Chemotherapy. 8 (1): 2–9. doi:10.1111/j.1476-5381.1953.tb00739.x. PMC 1509239. PMID 13066683.


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