Aminophenazone

Aminophenazone was first synthesized by Friedrich Stolz and Ludwig Knorr in the late nineteenth century, and sold as an anti-fever medicine known as Pyramidon by Hoechst AG from 1897 until its eventual replacement by the safer propyphenazone molecule.

Symptoms of exposure to this compound include:[3]

• allergic reactions
• strong spasmolytic effect on smooth muscle of peripheral blood vessels
• irritability
• palsy
• copious sweating
• dilated pupils
• sharp drop then rise in body temperature
• dysuria
• dyspnea
• anxiety
• rectal tenesmus
• urinary frequency
• intermittent fever
• fatty infiltration of the liver
• heart muscle degeneration
• death due to circulatory failure following cardiovascular collapse

Agranulocytosis often occurs. Ingestion may cause central nervous system stimulation, vomiting, convulsions, cyanosis, tinnitus, leukopenia, kidney damage and coma. Ingestion may also lead to nausea, mental disturbances, methemoglobinemia, chocolate-colored blood, dizziness, epigastric pain, difficulty in hearing, thready pulse and liver damage.

Other symptoms reported via ingestion include hemolytic anemia, porphyria and severe gastrointestinal bleeding. Bone marrow depression also occurs. Rare eye effects include acute transient myopia.

Chronic symptoms include:

• anorexia
• edema
• oliguria
• urticaria
• hypersensitivity
• aplastic anemia
• sore throat
• fever
• pharyngeal membrane
• jaundice enlargement of the liver and spleen
• exfoliative dermatitis
• gastric or duodenal erosion with perforation or bleeding
• adrenal necrosis
• thrombocytopenic purpura
• acute leukemia

When heated to decomposition this compound emits toxic fumes of nitrogen oxides.

Amidopyrine is metabolized by demethylation and acetylation. Amidopirina metabolites are 4-aminoantipyrine, metilaminoantipirin, rubazonovaya and metilrubazonovaya acid. These acids have a reddish color. Due to the presence in the urine of these acids makers amidopirina high doses, it can have a reddish brownish coloration.[4]