Chlorzoxazone

Chlorzoxazone (INN) is a centrally acting muscle relaxant used to treat muscle spasm and the resulting pain or discomfort. It acts on the spinal cord by depressing reflexes. It is sold under the trade names "'Lorzone'", Paraflex and Muscol and in combination form as Parafon Forte, a combination of chlorzoxazone and acetaminophen (paracetamol). Possible side effects include dizziness, lightheadedness, malaise, nausea, vomiting, and liver dysfunction. Used with acetaminophen it has added risk of hepatoxicity, which is why the combination is not recommended. It can also be administered for acute pain in general and for tension headache (muscle contraction headache).

Chlorzoxazone
Clinical data
Trade namesParafonforte
AHFS/Drugs.comMonograph
MedlinePlusa682577
Routes of
administration		oral
ATC code
Pharmacokinetic data
Bioavailabilitywell absorbed
Protein binding13–18%
Metabolismhepatic
Elimination half-life1.1 hr
Excretionurine (<1%)
Identifiers
CAS Number
PubChem CID
IUPHAR/BPS
DrugBank
ChemSpider
UNII
KEGG
ChEBI
ChEMBL
CompTox Dashboard (EPA)
ECHA InfoCard100.002.186
Chemical and physical data
FormulaC7H4ClNO2
Molar mass169.565 g/mol g·mol−1
3D model (JSmol)
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Like metaxalone, no specific mechanism of action has been identified for chlorzoxazone, with general central nervous system depression being the only currently accepted aspect to its medical benefits. Search for the exact mechanism of action is ongoing but limited due to the existence of more-effective safe muscle relaxers (ex. diazepam, cyclobenzaprine, tizanidine) greatly limiting the potential benefit of identifying novel compounds which share chlorzoxazone's mechanism of action.

As of 2015 the cost for a typical course of medication in the United States is less than US$25.[1]

See also

References

[2]

  1. Hamilton, Richart (2015). Tarascon Pocket Pharmacopoeia 2015 Deluxe Lab-Coat Edition. Jones & Bartlett Learning. p. 1. ISBN 9781284057560.
  2. Chloroxazone Safety Data Sheet


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