Amlodipine/benazepril

Amlodipine/benazepril, marketed as Lotrel among others, is a medication used to treat high blood pressure.[1] It is a combination of amlodipine, a calcium channel blocker and benazepril, an angiotensin converting enzyme inhibitor.[1] It may be used if a single agent is not sufficient.[1] It is taken by mouth.[1]

Amlodipine/benazepril
Combination of
AmlodipineCalcium channel blocker
BenazeprilACE inhibitor
Clinical data
Pregnancy
category
  • US: D (Evidence of risk)
    Routes of
    administration    		By mouth
    ATC code
    • None
    Legal status
    Legal status
    Identifiers
    CAS Number
    PubChem CID
    ChemSpider
    KEGG
    CompTox Dashboard (EPA)
     NY (what is this?)  (verify)

    Common side effects include cough, dizziness, and swelling.[1] Serious side effects may include angioedema, myocardial infarction, high blood potassium, liver problems, and low blood pressure.[1] Use in pregnancy is not recommended.[1] Amlodipine works by increasing the size of arteries while benazepril works by decreasing renin-angiotensin-aldosterone system activity.[1]

    The combination was approved for medical use in the United States in 1995.[2] It is available as a generic medication.[3] A month supply in the United States has a wholesale cost of about US$4.50.[4] In 2016 it was the 140th most prescribed medication in the United States with more than 4 million prescriptions.[5]

    Medical use

    It is used to treat high blood pressure.[1] It is not a first line treatment.[6]

    References
    1. "DailyMed - AMLODIPINE BESYLATE AND BENAZEPRIL HYDROCHLORIDE- amlodipine besylate and benazepril hydrochloride capsule". dailymed.nlm.nih.gov. Retrieved 10 March 2019.
    2. "Amlodipine and benazepril Uses, Side Effects & Warnings". Drugs.com. Retrieved 10 March 2019.
    3. Bope, Edward T.; Kellerman, Rick D. (2016). Conn's Current Therapy 2017 E-Book. Elsevier Health Sciences. p. 124. ISBN 9780323443357.
    4. "NADAC as of 2019-02-27". Centers for Medicare and Medicaid Services. Retrieved 3 March 2019.
    5. "The Top 300 of 2019". clincalc.com. Retrieved 22 December 2018.
    6. Faulkner, MA; Hilleman, DE (January 2001). "Amlodipine/benazepril: fixed dose combination therapy for hypertension". Expert Opinion on Pharmacotherapy. 2 (1): 165–78. doi:10.1517/14656566.2.1.165. PMID 11336577.


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