Chloride channel opener
A chloride channel opener is a type of drug which facilitates ion transmission through chloride channels.
An example is 1,10-phenanthroline, which activates Cystic fibrosis transmembrane conductance regulator (CFTR) chloride channels.[1]
GABA-A receptor agonists (e.g lorazepam) may also be considered chloride channel openers
See also
References
- Duszyk M, MacVinish L, Cuthbert AW (October 2001). "Phenanthrolines--a new class of CFTR chloride channel openers". British Journal of Pharmacology. 134 (4): 853–64. doi:10.1038/sj.bjp.0704328. PMC 1573018. PMID 11606326.
Further reading
- Cuthbert AW (February 2001). "Assessment of CFTR chloride channel openers in intact normal and cystic fibrosis murine epithelia". British Journal of Pharmacology. 132 (3): 659–68. doi:10.1038/sj.bjp.0703859. PMC 1572602. PMID 11159718.
- Ramteke VD, Tandan SK, Kumar D, Aruna Devi R, Shukla MK, Ravi Prakash V (January 2009). "Increased hyperalgesia by 5-nitro-2, 3-(phenylpropylamino)-benzoic acid (NPPB), a chloride channel blocker in crush injury-induced neuropathic pain in rats". Pharmacology Biochemistry and Behavior. 91 (3): 417–22. doi:10.1016/j.pbb.2008.08.017. PMID 18775743.
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