Pheneturide

Pheneturide
Clinical data
AHFS/Drugs.com	International Drug Names
ATC code	N03AX13 (WHO) ;
Identifiers
	IUPAC name (RS)-N-Carbamoyl-2-phenyl-butanamide;
CAS Number	90-49-3 ;
PubChem CID	72060;
ChemSpider	65046 ;
UNII	878CEJ4HGX;
KEGG	D01190 ;
CompTox Dashboard (EPA)	DTXSID4020612 ;
ECHA InfoCard	100.001.817
Chemical and physical data
Formula	C11H14N2O2
Molar mass	206.241 g/mol g·mol−1
3D model (JSmol)	Interactive image;
Chirality	Racemic mixture
	SMILES O=C(N)NC(=O)C(c1ccccc1)CC;
	InChI InChI=1S/C11H14N2O2/c1-2-9(10(14)13-11(12)15)8-6-4-3-5-7-8/h3-7,9H,2H2,1H3,(H3,12,13,14,15) ; Key:AJOQSQHYDOFIOX-UHFFFAOYSA-N ;
(what is this?) (verify)

Pheneturide (INN, BAN) (brand names Benuride, Deturid, Pheneturid, Septotence, Trinuride),[1] also known as phenylethylacetylurea (or ethylphenacemide), is an anticonvulsant of the ureide class.[2][3] Conceptually, it can be formed in the body as a metabolic degradation product from [[phenobarbital]]. It is considered to be obsolete,[4] and is now seldom used.[5] It is marketed in Europe, including in Poland, Spain, and the United Kingdom.[6] Pheneturide has a similar profile of anticonvulsant activity and toxicity relative to phenacemide,[7] but is less toxic in comparison, despite still being a toxic drug.[8] As such, it is only used in cases of severe epilepsy when other, less-toxic drugs have failed.[8] Pheneturide inhibits the metabolism and thus increases the levels of other anticonvulsants, such as phenytoin.[5][6]

References

Muller (19 June 1998). European Drug Index: European Drug Registrations, Fourth Edition. CRC Press. pp. 998–. ISBN 978-3-7692-2114-5.
J. Elks (14 November 2014). The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies. Springer. pp. 959–. ISBN 978-1-4757-2085-3.
Byrne B, Rothchild R (1999). "1H NMR studies of drugs with achiral and chiral lanthanide shift reagents: applications to the anticonvulsant pheneturide". Chirality. 11 (7): 529–35. doi:10.1002/(SICI)1520-636X(1999)11:7<529::AID-CHIR3>3.0.CO;2-K. PMID 10423278.
René H. Levy (2002). Antiepileptic Drugs. Lippincott Williams & Wilkins. pp. 210–. ISBN 978-0-7817-2321-3.
M.J. Denham (6 December 2012). The Treatment of Medical Problems in the Elderly. Springer Science & Business Media. pp. 335–. ISBN 978-94-011-6223-4.
Julius Vida (19 July 2013). Anticonvulsants. Elsevier. pp. 4, 42. ISBN 978-0-323-14395-0.
deStevens, G.; Zingel, V.; Leschke, C.; Hoeprich, P.D.; Schultz, R.M.; Mehrotra, P.K.; Batra, S.; Bhaduri, A.P.; Saxena, A.K.; Saxena, M., eds. (11 November 2013). Progress in Drug Research / Fortschritte der Arzneimittelforschung / Progrès des Recherches Pharmaceutiques. Basel: Birkhäuser. pp. 217–. ISBN 978-3-0348-7161-7. Retrieved 3 September 2016.
Richard Lancaster (22 October 2013). Pharmacology in Clinical Practice. Elsevier. pp. 222–. ISBN 978-1-4831-9294-9.

This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.

[Muller1998-1] Muller (19 June 1998). European Drug Index: European Drug Registrations, Fourth Edition. CRC Press. pp. 998–. ISBN 978-3-7692-2114-5.

[Elks2014-2] J. Elks (14 November 2014). The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies. Springer. pp. 959–. ISBN 978-1-4757-2085-3.

[pmid10423278-3] Byrne B, Rothchild R (1999). "1H NMR studies of drugs with achiral and chiral lanthanide shift reagents: applications to the anticonvulsant pheneturide". Chirality. 11 (7): 529–35. doi:10.1002/(SICI)1520-636X(1999)11:7<529::AID-CHIR3>3.0.CO;2-K. PMID 10423278.

[Levy2002-4] René H. Levy (2002). Antiepileptic Drugs. Lippincott Williams & Wilkins. pp. 210–. ISBN 978-0-7817-2321-3.

[Denham2012-5] M.J. Denham (6 December 2012). The Treatment of Medical Problems in the Elderly. Springer Science & Business Media. pp. 335–. ISBN 978-94-011-6223-4.

[Vida2013-6] Julius Vida (19 July 2013). Anticonvulsants. Elsevier. pp. 4, 42. ISBN 978-0-323-14395-0.

[deStevensZingel2013-7] Stevens, G.; Zingel, V.; Leschke, C.; Hoeprich, P.D.; Schultz, R.M.; Mehrotra, P.K.; Batra, S.; Bhaduri, A.P.; Saxena, A.K.; Saxena, M., eds. (11 November 2013). Progress in Drug Research / Fortschritte der Arzneimittelforschung / Progrès des Recherches Pharmaceutiques. Basel: Birkhäuser. pp. 217–. ISBN 978-3-0348-7161-7. Retrieved 3 September 2016.

[Lancaster2013-8] Richard Lancaster (22 October 2013). Pharmacology in Clinical Practice. Elsevier. pp. 222–. ISBN 978-1-4831-9294-9.

Pheneturide

See also

References