Amlodipine/valsartan

Amlodipine/valsartan is a blood pressure lowering combination drug. It contains amlodipine, a dihydropyridine-type calcium channel blocker, and valsartan, an angiotensin receptor blocker. This combination is usually well tolerated and effective for the reduction of blood pressure.[1]

Amlodipine/valsartan
Combination of
AmlodipineCalcium channel blocker
ValsartanAngiotensin II receptor antagonist
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  • US: D (Evidence of risk)
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    administration    		Oral
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    The combination was originally patented by Novartis Pharmaceuticals under the brand name Exforge. The patent expired in September 2012.[2]

    Amlodipine/valsartan is available in different dose preparations: 5 mg/80 mg, 5 mg/160 mg, 10 mg/160 mg, 5 mg/320 mg and 10/320 mg of amlodipine and valsartan, respectively.

    The combination is also available with included hydrochlorothiazide, for patients who need a three-drug regimen to manage their blood pressure.

    References
    1. Eckert, Siegfried; Freytag, Siegfried B.; Müller, Alfons; Klebs, Sven H. G. (2013). "Meta-analysis of three observational studies of amlodipine/valsartan in hypertensive patients with additional risk factors". Blood Pressure. 22 (sup1): 11–21. doi:10.3109/08037051.2013.793891. ISSN 0803-7051.
    2. "Generic Exforge HCT". Blood-pressure.emedtv.com. Retrieved 2012-03-05.


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