Delapril

Delapril (INN, also known as alindapril) is an ACE inhibitor used as an antihypertensive drug[1] in some European and Asian countries but not in America.[2] It is taken orally, available in 15 mg and 30 mg tablets.[3]

Delapril
Clinical data
AHFS/Drugs.comInternational Drug Names
ATC code
Identifiers
CAS Number
PubChem CID
ChemSpider
UNII
KEGG
ChEMBL
Chemical and physical data
FormulaC26H32N2O5
Molar mass452.542 g/mol g·mol−1
3D model (JSmol)
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Mechanism

Delapril is a prodrug; it is converted into two active metabolites, 5-hydroxy delapril diacid and delapril diacid. These metabolites bind completely to and inhibit angiotensin-converting enzyme (ACE), hence blocking angiotensin I to angiotensin II conversion. The resulting vasodilation prevents the vasoconstrictive effects of angiotensin II. Angiotensin II-induced aldosterone secretion by the adrenal cortex is also decreased by Delapril, leading to increases in excretion of sodium and therefore increases water outflow.[4]

References
  1. Otero, M. L. (2007). "Manidipine-delapril combination in the management of hypertension". Vascular Health and Risk Management. 3 (3): 255–263. PMC 2293964. PMID 17703633.
  2. Drugs.com: Delapril
  3. "cursoenarm.net/UPTODATE/contents/mobipreview.htm?16/0/16396?source=HISTORY". cursoenarm.net. Retrieved 2016-08-28.
  4. Pubchem. "DELAPRIL | C26H32N2O5 - PubChem". pubchem.ncbi.nlm.nih.gov. Retrieved 2016-08-28.


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