Hematoporphyrin
Hematoporphyrin (Photodyn, Sensibion) is a porphyrin prepared from hemin. It is a derivative of protoporphyrin IX, where the two vinyl groups have been hydrated (converted to alcohols). It is a deeply colored solid that is usually encountered as a solution. Its chemical structure was determined in 1900.[1]
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| Routes of administration | Oral |
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| ECHA InfoCard | 100.034.939  |
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| Formula | C34H38N4O6 |
| Molar mass | 598.69 g/mol g·mol−1 |
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| Melting point | 172.5 °C (342.5 °F) |
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It is used as a photosensitizer in photodynamic therapy. Acetylation of hematoporphyrin followed by hydrolysis of the product of that reaction affords a mixture called hematoporphyrin derivative (HPD), which is also used in photodynamic therapy.[2]
Hematoporphyrin has also been used as an antidepressant and antipsychotic since the 1920s.[3][4]
References
- Evstigneeva, R. P.; Filippovich, E. I.; Luzgina, V. N. (May 1977). "SpringerLink - Journal Article". Pharmaceutical Chemistry Journal. 11 (5): 613–620.
- David Kessel (1984). "Hematoporphyrin and HPD: Photophysics, Photochemistry And Phototherapy". Photochemistry and Photobiology. 39: 851–859. doi:10.1111/j.1751-1097.1984.tb08871.x.
- O'Neil, Maryadele J. (2001). The Merck index: an encyclopedia of chemicals, drugs, and biologicals. Rahway, NJ: Merck Research Laboratories. ISBN 0-911910-13-1.
- "Hematoporphyrin as a Therapeutic Agent in the Psychoses -- Strecker et al. 90 (6): 1157 -- Am J Psychiatry".
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