Pirlindole
Pirlindole (Lifril, Pyrazidol) is a reversible inhibitor of monoamine oxidase A (RIMA) which was developed and is used in Russia as an antidepressant.[2]:337 It is structurally and pharmacologically related to metralindole.
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| Trade names | Pirazidol |
| Routes of administration | Oral |
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| Bioavailability | 20–30% |
| Protein binding | 95% |
| Metabolism | hepatic |
| Onset of action | 2 to 8 hours |
| Elimination half-life | 2.1 hours [1] |
| Excretion | urine (50–70%), feces (25–45%) |
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| Formula | C15H18N2 |
| Molar mass | 226.32 g/mol g·mol−1 |
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See also
References
- Pöldinger, W. (1985). Pirlindole: results of an open clinical study in out-patients and of a double-blind study against maprotiline. In Psychiatry the State of the Art (pp. 283-289). Springer, Boston, MA. ISBN 978-1-4613-2363-1
- Medvedev AE, et al. The influence of the antidepressant pirlindole and its dehydro-derivative on the activity of monoamine oxidase A and GABAA receptor binding. Chapter 36 in MAO - The Mother of all Amine Oxidases (Journal of Neural Transmission. Supplementa). Eds Finberg JPM, Youdim MBH, Riederer P, Tipton KF. Special edition of Journal of Neural Transmission, Suppl. 52 1st ed. 1998 ISBN 978-3211830376
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