CID-85469571

CID-85469571
Identifiers
	IUPAC name (2Z)-2-[(3-[(4-chlorophenyl)methoxy]phenyl)methylidene]-6,7-dihydro-5H-imidazo[2,1-b][1,3]thiazin-3-one;
PubChem CID	85469571;
ChemSpider	34226942;
Chemical and physical data
Formula	C20H17ClN2O2S
Molar mass	384.879 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES Clc4ccc(cc4)COc(c2)cccc2\C=C(\C1=O)/N=C3N1CCCS3;
	InChI InChI=1S/C20H17ClN2O2S/c21-16-7-5-14(6-8-16)13-25-17-4-1-3-15(11-17)12-18-19(24)23-9-2-10-26-20(23)22-18/h1,3-8,11-12H,2,9-10,13H2/b18-12-; Key:XJBQRMOGMULGPP-PDGQHHTCSA-N;

CID-85469571 is a compound which acts as an antagonist at the former orphan receptor GPR18, and is the first selective antagonist characterised for this receptor, with an IC₅₀ of 279nM, and good selectivity over related receptors (over 36x selectivity vs CB₁ and GPR55, and 14x vs CB₂.) As all previously known antagonists for GPR18 also antagonise GPR55, it has been difficult to separate the effects of these two receptor targets, so the discovery of a selective GPR18 antagonist is expected to be useful in research into the actions of this receptor.[1]

References

Rempel V, et al. Bicyclic imidazole-4-one derivatives: a new class of antagonists for the orphan G protein-coupled receptors GPR18 and GPR55. Med. Chem. Commun., 2014;5: 632-649. DOI 10.1039/C3MD00394A

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[1] Rempel V, et al. Bicyclic imidazole-4-one derivatives: a new class of antagonists for the orphan G protein-coupled receptors GPR18 and GPR55. Med. Chem. Commun., 2014;5: 632-649. DOI 10.1039/C3MD00394A

CID-85469571

See also

References