11-Hydroxy-THC

11-Hydroxy-THC
Identifiers
	IUPAC name (6aR,10aR)-9-(Hydroxymethyl)-6,6-dimethyl-3-pentyl- 6a,7,8,10a-tetrahydro-6H-benzo[c]chromen-1-ol;
CAS Number	36557-05-8 ;
PubChem CID	37482;
ChemSpider	34385 ;
CompTox Dashboard (EPA)	DTXSID50190061 ;
ECHA InfoCard	100.164.583
Chemical and physical data
Formula	C21H30O3
Molar mass	330.461 g/mol g·mol−1
3D model (JSmol)	Interactive image;
	SMILES Oc2cc(cc1OC(C3CC/C(=C\C3c12)CO)(C)C)CCCCC;
	InChI InChI=1S/C21H30O3/c1-4-5-6-7-14-11-18(23)20-16-10-15(13-22)8-9-17(16)21(2,3)24-19(20)12-14/h10-12,16-17,22-23H,4-9,13H2,1-3H3 ; Key:YCBKSSAWEUDACY-UHFFFAOYSA-N ;
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11-Hydroxy-Δ⁹-tetrahydrocannabinol (11-OH-THC), usually referred to as 11-hydroxy-THC, is the main active metabolite of tetrahydrocannabinol (THC), which is formed in the body after decarboxylated cannabis is consumed.[1][2]

Fresh cannabis contains tetrahydrocannabinolic acid (THCA), which is converted into THC after heating and then metabolized by the body into 11-hydroxy-THC and then into 11-nor-9-carboxy-THC;[2] both compounds can be glucuronidated and mainly excreted into urine. Both compounds, along with THC, are assayed in blood tests.[1]

References

Kraemer, T; Paul, LD (August 2007). "Bioanalytical procedures for determination of drugs of abuse in blood". Analytical and Bioanalytical Chemistry. 388 (7): 1415–35. doi:10.1007/s00216-007-1271-6. PMID 17468860.
Huestis, MA (2005). "Pharmacokinetics and metabolism of the plant cannabinoids, delta9-tetrahydrocannabinol, cannabidiol and cannabinol". Handbook of experimental pharmacology (168): 657–90. doi:10.1007/3-540-26573-2_23. PMID 16596792.

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[Kraemer2007-1] Kraemer, T; Paul, LD (August 2007). "Bioanalytical procedures for determination of drugs of abuse in blood". Analytical and Bioanalytical Chemistry. 388 (7): 1415–35. doi:10.1007/s00216-007-1271-6. PMID 17468860.

[Huestis2005-2] Huestis, MA (2005). "Pharmacokinetics and metabolism of the plant cannabinoids, delta9-tetrahydrocannabinol, cannabidiol and cannabinol". Handbook of experimental pharmacology (168): 657–90. doi:10.1007/3-540-26573-2_23. PMID 16596792.

11-Hydroxy-THC

See also

References