JWH-398

JWH-398 is an analgesic chemical from the naphthoylindole family, which acts as a cannabinoid agonist at both the CB1 and CB2 receptors. It has mild selectivity for CB1 with a Ki of 2.3 nM and 2.8 nM at CB2.[2] This synthetic chemical compound was identified by the EMCDDA as an ingredient in three separate "herbal incense" products purchased from online shops between February to June 2009.[3] It was discovered by, and named after, John W. Huffman.[4]

JWH-398
Legal status
Legal status
Identifiers
CAS Number
ChemSpider
CompTox Dashboard (EPA)
Chemical and physical data
FormulaC24H22ClNO
Molar mass375.90 g·mol−1
3D model (JSmol)
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In the United States, JWH-398 is a Schedule I controlled substance.[5]

See also

References

  1. Grozījumi Ministru kabineta 2005.gada 8.novembra noteikumos Nr.847 "Noteikumi par Latvijā kontrolējamajām narkotiskajām vielām, psihotropajām vielām un prekursoriem"
  2. Huffman J.W. (2009). Reggio P.H. (ed.). Cannabimimetic Indoles, Pyrroles, and Indenes: Structure–Activity Relationships and Receptor Interactions. The Cannabinoid Receptors. The Receptors. Humana Press. doi:10.1007/978-1-59745-503-9. ISBN 978-1-58829-712-9.
  3. Understanding the ‘Spice’ phenomenon. EMCDDA, Lisbon, November 2009
  4. John W. Huffman, et al. STRUCTURE-ACTIVITY RELATIONSHIPS AT THE CB1 AND CB2 RECEPTORS FOR 1-ALKYL-3-(1-NAPHTHOYL-4 AND 8-HALOGEN SUBSTITUTED) INDOLES (2009) 19th Annual Symposium on the Cannabinoids, Burlington, Vermont, International Cannabinoid Research Society, Page 2.
  5. Controlled Substances listed by the DEA
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