JWH-081
JWH-081 is an analgesic chemical from the naphthoylindole family, which acts as a cannabinoid agonist at both the CB1 and CB2 receptors.[2] With a Ki of 1.2nM it is fairly selective for the CB1 subtype, its affinity at this subtype approximately 10x the affinity at CB2.[3] It was discovered by and named after John W. Huffman.
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ECHA InfoCard | 100.230.181 |
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Formula | C25H25NO2 |
Molar mass | 371.480 g·mol−1 |
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JWH-081 may be neurotoxic to animals when administered in high doses.[4]
Legal status
In the United States, JWH-081 is a Schedule I Controlled Substance.[5]
As of October 2015, JWH-081 is a controlled substance in China.[6]
References
- "Ustawa z dnia 15 kwietnia 2011 r. o zmianie ustawy o przeciwdziałaniu narkomanii (Dz.U. 2011 nr 105 poz. 614)". Internetowy System Aktów Prawnych. Retrieved 12 June 2011.
- Aung MM, et al. Influence of the N-1 alkyl chain length of cannabimimetic indoles upon CB1 and CB2 receptor binding. Drug and Alcohol Dependence 2000; 60:133-140.
- Huffman JW, et al. Structure–activity relationships for 1-alkyl-3-(1-naphthoyl)indoles at the cannabinoid CB1 and CB2 receptors: steric and electronic effects of naphthoyl substituents. New highly selective CB2 receptor agonists. Bioorganic & Medicinal Chemistry. 2005; 13:89-112.
- Hye Jin Cha; Yeon-Hee Seong; Min-Ji Song; Ho-Sang Jeong; Jisoon Shin; Jaesuk Yun; Kyoungmoon Han; Young-Hoon Kim; Hoil Kang; Hyoung Soo Kim (November 2015). "Neurotoxicity of Synthetic Cannabinoids JWH-081 and JWH-210". Biomolecules & Therapeutics. 23 (6): 597–603. doi:10.4062/biomolther.2015.057. PMC 4624077. PMID 26535086.
- Controlled Substances listed by the DEA
- "关于印发《非药用类麻醉药品和精神药品列管办法》的通知" (in Chinese). China Food and Drug Administration. 27 September 2015. Retrieved 1 October 2015.
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