JWH-030

JWH-030
Legal status
Legal status	US: Schedule I ;
Identifiers
	IUPAC name Naphthalen-1-yl-(1-pentylpyrrol-3-yl)methanone;
CAS Number	162934-73-8 ;
PubChem CID	9971539;
ChemSpider	8147131;
ChEMBL	ChEMBL71810;
CompTox Dashboard (EPA)	DTXSID10433522 ;
Chemical and physical data
Formula	C20H21NO
Molar mass	291.394 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES CCCCCn3cc(cc3)C(=O)c1cccc2ccccc12;
	InChI InChI=1S/C20H21NO/c1-2-3-6-13-21-14-12-17(15-21)20(22)19-11-7-9-16-8-4-5-10-18(16)19/h4-5,7-12,14-15H,2-3,6,13H2,1H3; Key:VPBJQDBKZSHCPC-UHFFFAOYSA-N;
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JWH-030 is a research chemical which is a cannabinoid receptor agonist.[1] It has analgesic effects and is used in scientific research.[2] It is a partial agonist at CB₁ receptors, with a K_i of 87 nM, making it roughly half the potency of THC.[3] It was discovered and named after John W. Huffman.

In the United States, CB₁ receptor agonists of the 3-(1-naphthoyl)pyrrole class such as JWH-030 are Schedule I Controlled Substances.[4]

References

Lainton JAH, Huffman JW, Martin BR, Compton DR. Tetrahedron Letters. 1995; 36:1401.
Pertwee RG, Griffin, G, Lainton JAH, Huffman JW. European Journal of Pharmacology. 1995; 284:241.
Griffin, G.; Atkinson, P. J.; Showalter, V. M.; Martin, B. R.; Abood, M. E. (1998). "Evaluation of cannabinoid receptor agonists and antagonists using the guanosine-5'-O-(3-35Sthio)-triphosphate binding assay in rat cerebellar membranes". The Journal of Pharmacology and Experimental Therapeutics. 285 (2): 553–560. PMID 9580597.
21 U.S.C. § 812: Schedules of controlled substances

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[1] Lainton JAH, Huffman JW, Martin BR, Compton DR. Tetrahedron Letters. 1995; 36:1401.

[2] Pertwee RG, Griffin, G, Lainton JAH, Huffman JW. European Journal of Pharmacology. 1995; 284:241.

[3] Griffin, G.; Atkinson, P. J.; Showalter, V. M.; Martin, B. R.; Abood, M. E. (1998). "Evaluation of cannabinoid receptor agonists and antagonists using the guanosine-5'-O-(3-35Sthio)-triphosphate binding assay in rat cerebellar membranes". The Journal of Pharmacology and Experimental Therapeutics. 285 (2): 553–560. PMID 9580597.

[4] 21 U.S.C. § 812: Schedules of controlled substances

JWH-030

See also

References