Reactive gastropathy

Reactive gastropathy, chemical gastropathy also called gastritis of « C type » or "chemical gastritis"[1] is an abnormality in the stomach caused by chemicals, e.g. bile, alcohol, and characteristically has minimal inflammation.

Reactive gastropathy
Micrograph of a reactive gastropathy. H&E stain.
SpecialtyPathology, gastroenterology

Cause

Reactive gastropathy has a large number of causes, including:

Diagnosis

The diagnosis is by examination of tissue, e.g. a stomach biopsy.

It is characterized, histologically, by:[2]

  1. foveolar hyperplasia with gland tortuosity and dilation,
  2. smooth muscle hyperplasia in the lamina propria, and
  3. scant or minimal inflammation, i.e. lack of large numbers of neutrophils and plasma cells.

Relation to gastritis

Reactive gastropathy is morphologically distinct entity[3][4] that can be separated from gastritis, which by definition has a significant inflammatory component.

As a reactive gastropathy may mimic a (true) gastritis symptomatically and visually in an endoscopic examination, it may incorrectly be referred to as a gastritis. Even aware of the underlying etiology of the pathologic process, e.g. NSAID use, the label "chemical gastritis" is applied to a chemical gastropathy.

See also

References

  1. Wyatt JI, Dixon MF (1988). "Chronic gastritis—a pathogenesis approach". The Journal of Pathology. 40 (154): 113–24. doi:10.1002/path.1711540203. PMID 3280764.CS1 maint: uses authors parameter (link)
  2. Genta, RM (Nov 2005). "Differential diagnosis of reactive gastropathy". Seminars in Diagnostic Pathology. 22 (4): 273–83. doi:10.1053/j.semdp.2006.04.001. PMID 16939055.
  3. Pashankar, DS; Bishop, WP; Mitros, FA (Nov 2002). "Chemical gastropathy: a distinct histopathologic entity in children". Journal of Pediatric Gastroenterology and Nutrition. 35 (5): 653–7. doi:10.1097/00005176-200211000-00012. PMID 12454581.
  4. Dixon, MF; O'Connor, HJ; Axon, AT; King, RF; Johnston, D (May 1986). "Reflux gastritis: distinct histopathological entity?". Journal of Clinical Pathology. 39 (5): 524–30. doi:10.1136/jcp.39.5.524. PMC 499914. PMID 3722405.
Classification
External resources
This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.